Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma

BMC Systems Biology

Table 1 The 35 microRNA that distinguish tumor from normal tissue in human ccRCC.

microRNA	Expression Status in ccRCC	Hystotype (from references: [5–22, 35–40, 65, 66, 73, 74, 79])	Cancer-related Regions[17, 18]
Name
miR-100	Down	Up in pancreas, stomach	11q23-q24 (D)
		Down in ovarian
miR-10b	Down	Down in breast
miR-125b	Down	Up in pancreas	11q23 (D)
		Down in breast
miR-26a⁺	Down	Down in epithelial cancers	3p21.3 (D)
miR-133b	Down	Down in ovarian
miR-135a	Down		3p21.1-21.2 (D)
miR-135b	Down
miR-136	Down		14q32 (D)
miR-141	Down	Up in lung, ovarian
miR-149	Down		2q37 (D)
miR-154	Down	Down in ovarian	14q32 (D)
miR-199a	Down	Up in lung, pancreas, prostate
		Down in ovarian
miR-200a*	Down	Up in ovarian
miR-200b	Down	Up in lung, ovarian
miR-200c	Down	Up in ovarian
miR-204	Down	Down in ovarian
miR-211	Down
miR-218	Down		4p15.3 (D)
miR-30a-3p	Down
miR-30a-5p	Down	Down in lung
miR-337	Down		14q32 (D)
miR-377	Down
miR-411	Down		14q32 (D)
miR-429	Down
miR-507	Down
miR-510	Down
miR-514	Down
miR-142-3p	Up
miR-155	Up	Up in breast, colon, lung	21q21 (A)
miR-185	Up	Up in kidney, bladder
miR-21	Up	Up in breast, colon, lung, pancreas, prostate, stomach,; gliobastoma cervical	17q23.2 (A)
miR-210	Up	Up in breast
miR-224	Up	Down in lung, ovarian	Xq28
miR-34a	Up	Up in lung, rat RCC	11q23-q24 (D)
		Down in neuroblastoma
miR-34b	Up
miR-592	Up

Cancer-related regions listed are either deleted regions (D), amplified regions (A) or breakpoint regions.

ISSN: 1752-0509