Figure 6

Verification of CtrA and DnaA binding site prediction. A. Number of genes putatively controlled by CtrA (dark gray) and DnaA (light gray) across alpha-proteobacteria. B. Distribution of p-values assigned to each gene with respect to the CtrA binding and DnaA binding for three alpha-proteobacteria (CCRE = C. crescentus, BABO = B. abortus, SMELI = S. meliloti) and species, possessing only DnaA (ECOLI = E. coli, BSUB = B. subtilis). The distributions of CCRE, BABO, SMELI for CtrA start to diverge from the 'background' distributions represented by organisms not possessing CtrA at a p < 0.05, while for DnaA this distribution is uniform among all five organisms. C. Consensus sequences of DnaA and CtrA in different bacteria found experimentally elsewhere (see references near the sequences) compared with our PMWs. M = T or G, W = A or T.