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Table 2 Partial flux control coefficients for glucose-6-phosphate isomerase (r2)

From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

 

Partial flux control coefficient through

 

Enzyme

G6Pin

F6Pin

6PGin

Flux control coefficient

r1

5.64

-2.31

-3.18

0.15

r2

-0.61

-0.52

0.24

0.11

r3

-0.34

0.33

0.14

0.13

r4

-0.44

0.42

0.18

0.16

r5

-0.06

0.06

0.02

0.02

r6

-1.11

0.74

0.76

0.38

r7

-0.02

0.01

0.01

0.01

r8

-0.06

0.03

0.04

0.02

r9

0.00

0.00

0.00

0.00

r10

6.68

4.09

-12.40

-1.63

r11

0.30

0.19

-0.56

-0.07

r12

-3.12

-2.86

6.49

0.50

r13

0.19

-0.21

-0.05

-0.07

r14

-5.06

-2.90

8.98

1.02

r15

1.16

-1.20

-0.40

-0.44

r16

-1.91

1.62

0.97

0.69

r17

0.00

0.00

0.00

0.00

r18

-2.24

1.85

1.20

0.81

r19

-1.42

-0.03

1.12

-0.33

r20

0.02

-0.01

-0.02

-0.01

r21

0.00

0.00

0.00

0.00

r22

0.78

1.37

-2.69

-0.54

r23

-0.02

0.01

0.01

0.00

r24

0.10

-0.10

-0.03

-0.04

r25

-0.04

-0.01

0.06

0.01

r26

-0.01

0.00

0.00

0.00

r27

-0.05

0.00

0.06

0.01

r28

0.04

-0.02

-0.03

-0.01

r29

0.62

-0.39

-0.42

-0.20

r30

-0.08

0.09

0.02

0.03

r31

-0.14

0.17

0.03

0.06

r32

-0.08

0.10

0.02

0.04

r33

-0.02

0.06

-0.02

0.02

r34

-0.02

0.05

-0.02

0.02

r35

0.18

-0.11

-0.12

-0.06

r36

2.15

-1.36

-1.46

-0.67

r37

-0.01

0.01

0.00

0.00

r38

-0.10

0.05

0.08

0.03

r39

0.17

-0.32

0.05

-0.09

r40

-0.03

0.09

-0.03

0.03

r41

-4.38

2.55

3.32

1.48

r42

0.37

-0.42

-0.10

-0.15

r43

-0.45

0.57

0.09

0.21

r44

0.09

-0.13

0.00

-0.04

r45

-0.05

0.04

0.03

0.02

r46

1.82

-0.94

-1.40

-0.53

r47

1.24

-0.51

-0.70

0.03

r48

0.12

-0.05

-0.11

-0.03

r49

0.18

-0.10

-0.14

-0.06

  1. Partial flux control coefficients are only shown for metabolites that have an effect on the glucose-6-phosphate isomerase (r2), i.e. that have non-zero elasticities. The sum of the partial flux control coefficients over all intermediates equals the flux control coefficient. With regard to the control of an enzyme over its own flux, the flux control coefficient equals the sum of the partial flux control coefficients plus one.