From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells
 | r33 | r34 | r40 | r43 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Partial flux control coefficient through | Flux control coefficient | Partial flux control coefficient through | Flux control coefficient | Partial flux control coefficient through | Flux control coefficient | Partial flux control coefficient through | Flux control coefficient | ||||||||||
Enzyme | ATPin | SUCin | SUCCOAin | ADPin | Â | MALin | FUMin | Â | NADin | SUCin | FUMin | NADHin | Â | PYRin | NADPin | MALin | NADPHin | Â |
r1 | -0.005 | -0.196 | 0.018 | -0.002 | -0.185 | -0.598 | 0.414 | -0.185 | 0.000 | 0.126 | -0.247 | -0.063 | -0.185 | -0.060 | -0.127 | 0.085 | -0.227 | -0.328 |
r2 | -0.003 | 0.003 | -0.001 | -0.001 | -0.002 | 0.089 | -0.091 | -0.002 | 0.000 | -0.002 | 0.055 | -0.055 | -0.002 | -0.025 | 0.017 | -0.013 | 0.030 | 0.009 |
r3 | -0.003 | -0.009 | 0.000 | -0.002 | -0.014 | 0.061 | -0.075 | -0.014 | 0.000 | 0.006 | 0.045 | -0.064 | -0.014 | -0.032 | 0.011 | -0.009 | 0.019 | -0.010 |
r4 | -0.004 | -0.012 | 0.000 | -0.002 | -0.018 | 0.077 | -0.094 | -0.018 | 0.000 | 0.008 | 0.056 | -0.081 | -0.018 | -0.040 | 0.014 | -0.011 | 0.024 | -0.013 |
r5 | -0.001 | -0.002 | 0.000 | 0.000 | -0.002 | 0.011 | -0.013 | -0.002 | 0.000 | 0.001 | 0.008 | -0.011 | -0.002 | -0.005 | 0.002 | -0.002 | 0.003 | -0.002 |
r6 | -0.009 | -0.028 | 0.000 | -0.005 | -0.042 | 0.178 | -0.220 | -0.042 | -0.001 | 0.018 | 0.132 | -0.191 | -0.042 | -0.093 | 0.031 | -0.025 | 0.056 | -0.032 |
r7 | 0.000 | 0.000 | 0.000 | 0.000 | -0.001 | 0.003 | -0.003 | -0.001 | 0.000 | 0.000 | 0.002 | -0.003 | -0.001 | -0.001 | 0.000 | 0.000 | 0.001 | 0.000 |
r8 | 0.000 | -0.006 | 0.001 | 0.000 | -0.006 | -0.026 | 0.020 | -0.006 | 0.000 | 0.004 | -0.012 | 0.002 | -0.006 | -0.021 | 0.002 | 0.004 | 0.003 | -0.013 |
r9 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
r10 | 0.036 | -0.544 | 0.064 | 0.019 | -0.425 | -3.145 | 2.720 | -0.425 | 0.003 | 0.349 | -1.624 | 0.847 | -0.425 | 0.315 | -0.631 | 0.449 | -1.131 | -0.998 |
r11 | 0.002 | -0.025 | 0.003 | 0.001 | -0.019 | -0.143 | 0.123 | -0.019 | 0.000 | 0.016 | -0.074 | 0.038 | -0.019 | 0.014 | -0.029 | 0.020 | -0.051 | -0.045 |
r12 | -0.012 | -0.047 | 0.001 | -0.006 | -0.065 | 0.196 | -0.261 | -0.065 | -0.001 | 0.030 | 0.156 | -0.250 | -0.065 | -0.125 | 0.033 | -0.028 | 0.060 | -0.060 |
r13 | 0.002 | 0.006 | 0.000 | 0.001 | 0.009 | -0.034 | 0.043 | 0.009 | 0.000 | -0.004 | -0.026 | 0.038 | 0.009 | 0.019 | -0.006 | 0.005 | -0.011 | 0.006 |
r14 | -0.026 | -0.090 | 0.002 | -0.013 | -0.127 | 0.422 | -0.549 | -0.127 | -0.002 | 0.058 | 0.328 | -0.510 | -0.127 | -0.253 | 0.073 | -0.060 | 0.131 | -0.108 |
r15 | 0.011 | 0.032 | 0.000 | 0.006 | 0.048 | -0.209 | 0.257 | 0.048 | 0.001 | -0.020 | -0.153 | 0.221 | 0.048 | 0.109 | -0.037 | 0.030 | -0.066 | 0.035 |
r16 | -0.017 | -0.050 | 0.000 | -0.009 | -0.075 | 0.322 | -0.398 | -0.075 | -0.001 | 0.032 | 0.238 | -0.344 | -0.075 | -0.170 | 0.057 | -0.046 | 0.102 | -0.056 |
r17 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | -0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
r18 | -0.019 | 0.532 | -0.058 | -0.010 | 0.446 | 2.173 | -1.728 | 0.446 | -0.001 | -0.342 | 1.031 | -0.243 | 0.446 | 1.168 | 0.052 | -0.310 | 0.093 | 1.003 |
r19 | 0.061 | -0.324 | 0.048 | 0.032 | -0.182 | -2.522 | 2.340 | -0.182 | 0.004 | 0.208 | -1.397 | 1.004 | -0.182 | -1.099 | 0.004 | 0.360 | 0.007 | -0.729 |
r20 | 0.000 | 0.000 | -0.001 | 0.000 | -0.001 | 0.004 | -0.005 | -0.001 | 0.000 | 0.000 | 0.003 | -0.004 | -0.001 | -0.002 | 0.000 | -0.001 | -0.001 | -0.004 |
r21 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | -0.001 | 0.001 | 0.000 | 0.000 | 0.000 | -0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
r22 | 0.002 | 0.751 | -0.074 | 0.001 | 0.680 | 2.787 | -2.107 | 0.680 | 0.000 | -0.482 | 1.258 | -0.096 | 0.680 | 0.069 | 0.579 | -0.398 | 1.037 | 1.287 |
r23 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | -0.001 | 0.000 | 0.000 | 0.001 | 0.000 |
r24 | 0.001 | 0.003 | 0.000 | 0.000 | 0.004 | -0.018 | 0.022 | 0.004 | 0.000 | -0.002 | -0.013 | 0.019 | 0.004 | 0.009 | -0.003 | 0.003 | -0.006 | 0.003 |
r25 | 0.000 | -0.002 | 0.000 | 0.000 | -0.002 | -0.012 | 0.010 | -0.002 | 0.000 | 0.001 | -0.006 | 0.003 | -0.002 | -0.007 | 0.001 | 0.002 | 0.001 | -0.004 |
r26 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | -0.002 | 0.002 | 0.000 | 0.000 | 0.000 | -0.001 | 0.001 | 0.000 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
r27 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.007 | -0.006 | 0.000 | 0.000 | 0.000 | 0.004 | -0.003 | 0.000 | -0.002 | 0.001 | -0.001 | 0.002 | 0.000 |
r28 | 0.000 | 0.005 | -0.001 | 0.000 | 0.005 | 0.023 | -0.019 | 0.005 | 0.000 | -0.003 | 0.011 | -0.003 | 0.005 | 0.018 | -0.001 | -0.003 | -0.002 | 0.011 |
r29 | 0.004 | 0.146 | -0.008 | 0.002 | 0.144 | 0.584 | -0.440 | 0.144 | 0.000 | -0.094 | 0.263 | -0.024 | 0.144 | 0.230 | -0.018 | -0.083 | -0.032 | 0.098 |
r30 | -0.001 | 0.010 | -0.001 | 0.000 | 0.008 | 0.077 | -0.069 | 0.008 | 0.000 | -0.006 | 0.041 | -0.027 | 0.008 | 0.009 | 0.003 | -0.011 | 0.005 | 0.005 |
r31 | -0.002 | 0.018 | -0.001 | -0.001 | 0.014 | 0.141 | -0.127 | 0.014 | 0.000 | -0.011 | 0.076 | -0.050 | 0.014 | 0.016 | 0.005 | -0.020 | 0.009 | 0.009 |
r32 | -0.001 | 0.010 | -0.001 | -0.001 | 0.008 | 0.084 | -0.075 | 0.008 | 0.000 | -0.007 | 0.045 | -0.030 | 0.008 | 0.009 | 0.003 | -0.012 | 0.005 | 0.005 |
r33 | -0.001 | -0.924 | -0.007 | 0.000 | 0.068 | -0.755 | 0.823 | 0.068 | 0.000 | 0.592 | -0.492 | -0.033 | 0.068 | 0.014 | 0.000 | 0.108 | -0.001 | 0.121 |
r34 | -0.001 | 0.071 | -0.007 | 0.000 | 0.063 | -0.703 | -0.234 | 0.063 | 0.000 | -0.046 | 0.139 | -0.030 | 0.063 | 0.013 | 0.000 | 0.100 | -0.001 | 0.112 |
r35 | 0.001 | 0.042 | -0.002 | 0.001 | 0.041 | 0.168 | -0.126 | 0.041 | 0.000 | -0.027 | 0.075 | -0.007 | 0.041 | 0.066 | -0.005 | -0.024 | -0.009 | 0.028 |
r36 | 0.013 | 0.503 | -0.026 | 0.007 | 0.497 | 2.012 | -1.515 | 0.497 | 0.000 | -0.323 | 0.904 | -0.084 | 0.497 | 0.793 | -0.061 | -0.287 | -0.109 | 0.337 |
r37 | 0.000 | -0.013 | 0.015 | 0.000 | 0.002 | -0.002 | 0.004 | 0.002 | 0.000 | 0.008 | -0.002 | -0.004 | 0.002 | 0.001 | 0.000 | 0.000 | 0.000 | 0.002 |
r38 | -0.001 | -0.014 | 0.002 | 0.000 | -0.013 | -0.070 | 0.057 | -0.013 | 0.000 | 0.009 | -0.034 | 0.012 | -0.013 | -0.049 | 0.003 | 0.010 | 0.005 | -0.031 |
r39 | 0.003 | -0.061 | 0.030 | 0.002 | -0.027 | -0.360 | 0.334 | -0.027 | 0.000 | 0.039 | -0.199 | 0.133 | -0.027 | -0.034 | -0.007 | 0.051 | -0.013 | -0.003 |
r40 | -0.001 | 0.119 | -0.011 | -0.001 | 0.106 | -1.177 | 1.284 | 0.106 | 0.000 | -0.076 | -0.766 | -0.051 | 0.106 | 0.022 | -0.001 | 0.168 | -0.001 | 0.188 |
r41 | -0.040 | -0.493 | 0.062 | -0.021 | -0.492 | -2.273 | 1.782 | -0.492 | 0.001 | 0.316 | -1.064 | 0.255 | -0.492 | -1.765 | 0.133 | 0.324 | 0.239 | -1.069 |
r42 | 0.004 | -0.032 | 0.022 | 0.002 | -0.004 | -0.235 | 0.231 | -0.004 | 0.000 | 0.021 | -0.138 | 0.112 | -0.004 | 0.053 | -0.013 | 0.034 | -0.023 | 0.050 |
r43 | -0.006 | 0.421 | -0.043 | -0.003 | 0.369 | 1.774 | -1.405 | 0.369 | -0.001 | -0.270 | 0.839 | -0.199 | 0.369 | -0.030 | 0.006 | -0.253 | 0.011 | 0.735 |
r44 | 0.001 | -0.051 | 0.011 | 0.001 | -0.038 | -0.239 | 0.201 | -0.038 | 0.000 | 0.032 | -0.120 | 0.049 | -0.038 | -0.100 | -0.002 | 0.034 | -0.004 | -0.073 |
r45 | 0.000 | 0.013 | -0.001 | 0.000 | 0.011 | 0.053 | -0.042 | 0.011 | 0.000 | -0.008 | 0.025 | -0.006 | 0.011 | 0.028 | 0.001 | -0.007 | 0.002 | 0.024 |
r46 | 0.009 | 0.260 | -0.033 | 0.005 | 0.241 | 1.285 | -1.044 | 0.241 | -0.001 | -0.167 | 0.623 | -0.214 | 0.241 | 0.888 | -0.052 | -0.183 | -0.094 | 0.558 |
r47 | -0.001 | -0.043 | 0.004 | -0.001 | -0.041 | -0.132 | 0.091 | -0.041 | 0.000 | 0.028 | -0.055 | -0.014 | -0.041 | -0.013 | -0.028 | 0.019 | -0.050 | -0.072 |
r48 | 0.001 | -0.002 | -0.005 | 0.000 | -0.005 | 0.022 | -0.027 | -0.005 | 0.000 | 0.001 | 0.016 | -0.023 | -0.005 | -0.013 | -0.003 | -0.003 | -0.005 | -0.024 |
r49 | 0.001 | 0.022 | -0.003 | 0.001 | 0.022 | 0.107 | -0.086 | 0.022 | 0.000 | -0.014 | 0.051 | -0.015 | 0.022 | 0.080 | -0.005 | -0.015 | -0.010 | 0.050 |