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Table 5 Activator and inhibitor influences

From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

Reaction Identifier EC-Number Activators Inhibitors
Glucokinase 2.7.1.2   F6P [76]
Glucose-6-phosphate isomerase 5.3.1.9   6PG [44]
6-phosphofructokinase 2.7.1.11 AMP [16] CIT [77]
Fructose-bisphosphate aldolase 4.1.2.13   ADP, ATP, E4P, F6P, G1P, G6P, RIBO5P [78]
Triose-phosphate isomerase 5.3.1.1   ATP [79]
Glyceraldehyde-3-phosphate dehydrogenase 1.2.1.12   ADP, ATP [80]
Phosphoglycerate kinase 2.7.2.3   AMP [81]
Pyruvate kinase 2.7.1.40 G6P, F6P, G1P [82], F16P [83] ALA [84]
Glucose-6-phosphate dehydrogenase 1.1.1.49   ATP [58]
Phosphoglucomutase 5.4.2.2   f16p [85]
UTP-glucose-1-phosphate uridylyltransferase 2.7.7.9   AMP [16]
Alpha-ketoglutarate dehydrogenase 1.2.4.2 ADP [86] ATP [86]
Valine, isoleucine, methionine metabolism - NAD, AKG [87] GLU, NADH [87]
Isocitrate dehydrogenase 1.1.1.41 ADP [88]  
Pyruvate dehydrogenase 1.2.4.1 AMP [89]  
  1. Regulatory influences and corresponding literature references. The modulator effects were included in the dynamic network model. In addition to these regulatory influences, the dynamic model did also account for substrate and product effects.