Table 5 Activator and inhibitor influences
From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells
| Reaction Identifier | EC-Number | Activators | Inhibitors |
|---|---|---|---|
| Glucokinase | 2.7.1.2 | F6P [76] | |
| Glucose-6-phosphate isomerase | 5.3.1.9 | 6PG [44] | |
| 6-phosphofructokinase | 2.7.1.11 | AMP [16] | CIT [77] |
| Fructose-bisphosphate aldolase | 4.1.2.13 | ADP, ATP, E4P, F6P, G1P, G6P, RIBO5P [78] | |
| Triose-phosphate isomerase | 5.3.1.1 | ATP [79] | |
| Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | ADP, ATP [80] | |
| Phosphoglycerate kinase | 2.7.2.3 | AMP [81] | |
| Pyruvate kinase | 2.7.1.40 | G6P, F6P, G1P [82], F16P [83] | ALA [84] |
| Glucose-6-phosphate dehydrogenase | 1.1.1.49 | ATP [58] | |
| Phosphoglucomutase | 5.4.2.2 | f16p [85] | |
| UTP-glucose-1-phosphate uridylyltransferase | 2.7.7.9 | AMP [16] | |
| Alpha-ketoglutarate dehydrogenase | 1.2.4.2 | ADP [86] | ATP [86] |
| Valine, isoleucine, methionine metabolism | - | NAD, AKG [87] | GLU, NADH [87] |
| Isocitrate dehydrogenase | 1.1.1.41 | ADP [88] | |
| Pyruvate dehydrogenase | 1.2.4.1 | AMP [89] |