From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells
Reaction Identifier | EC-Number | Activators | Inhibitors |
---|---|---|---|
Glucokinase | 2.7.1.2 | Â | F6P [76] |
Glucose-6-phosphate isomerase | 5.3.1.9 | Â | 6PG [44] |
6-phosphofructokinase | 2.7.1.11 | AMP [16] | CIT [77] |
Fructose-bisphosphate aldolase | 4.1.2.13 | Â | ADP, ATP, E4P, F6P, G1P, G6P, RIBO5P [78] |
Triose-phosphate isomerase | 5.3.1.1 | Â | ATP [79] |
Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | Â | ADP, ATP [80] |
Phosphoglycerate kinase | 2.7.2.3 | Â | AMP [81] |
Pyruvate kinase | 2.7.1.40 | ALA [84] | |
Glucose-6-phosphate dehydrogenase | 1.1.1.49 | Â | ATP [58] |
Phosphoglucomutase | 5.4.2.2 | Â | f16p [85] |
UTP-glucose-1-phosphate uridylyltransferase | 2.7.7.9 | Â | AMP [16] |
Alpha-ketoglutarate dehydrogenase | 1.2.4.2 | ADP [86] | ATP [86] |
Valine, isoleucine, methionine metabolism | - | NAD, AKG [87] | GLU, NADH [87] |
Isocitrate dehydrogenase | 1.1.1.41 | ADP [88] | Â |
Pyruvate dehydrogenase | 1.2.4.1 | AMP [89] | Â |