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Table 5 Activator and inhibitor influences

From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

Reaction Identifier EC-Number Activators Inhibitors
Glucokinase   F6P [76]
Glucose-6-phosphate isomerase   6PG [44]
6-phosphofructokinase AMP [16] CIT [77]
Fructose-bisphosphate aldolase   ADP, ATP, E4P, F6P, G1P, G6P, RIBO5P [78]
Triose-phosphate isomerase   ATP [79]
Glyceraldehyde-3-phosphate dehydrogenase   ADP, ATP [80]
Phosphoglycerate kinase   AMP [81]
Pyruvate kinase G6P, F6P, G1P [82], F16P [83] ALA [84]
Glucose-6-phosphate dehydrogenase   ATP [58]
Phosphoglucomutase   f16p [85]
UTP-glucose-1-phosphate uridylyltransferase   AMP [16]
Alpha-ketoglutarate dehydrogenase ADP [86] ATP [86]
Valine, isoleucine, methionine metabolism - NAD, AKG [87] GLU, NADH [87]
Isocitrate dehydrogenase ADP [88]  
Pyruvate dehydrogenase AMP [89]  
  1. Regulatory influences and corresponding literature references. The modulator effects were included in the dynamic network model. In addition to these regulatory influences, the dynamic model did also account for substrate and product effects.