Figure 5
From: Spatio-temporal modeling of signaling protein recruitment to EGFR
Comparison of the sharing and competing docking models. Simulations in (A-B) used the parameter values fitted to A431 cells data, while simulations in (C) used Kholodenko's parameter values [36]. (A) Results of simulations show similar number of adaptors docked to EGFR at steady state, when receptors are overexpressed and clustered. (B) Results of simulations for sharing and competing models at steady state, when receptors are at normal expression levels (50,000 receptors/cell) and either clustered or random. Receptor clustering increases the efficiency of adaptor retainment to EGFR, but sharing does not contribute further efficiency. (C) Results show that use of slow dissociation rates produces a dramatic increase in the shared docking of adaptors on EGFR tails, simulated for 50,000 clustered receptors in the spatial-stochastic model.