Effects of lineage and environment on pathway frequency, connectivity and centrality. The amplitude of variation of six scores of frequency, connectivity and centrality, and a p-value evaluating the significance of this variation are reported for all metabolic pathways. P-values were calculated by either a Fisher's Exact Test (frequency) or Mann-Whitney U-text (connectivity and centrality), and corrected for multiple testing using the Benjamini-Hochberg method . The median variation and the p-value for pathways in the same functional category were pictured as either a triangle or a diamond. A triangle pointing left (◀) means the score increases from left to right (e.g., from Prokarya to Eukarya), while a triangle pointing right (▶) means the score decreases from left to right. A diamond means the score does not change. The position of the symbol is proportional to the median corrected p-value, i.e. False Discovery Rate, and its size is proportional to the amplitude of variation. All values are available in Additional file 2. B.C.: Betweenness Centrality.