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Table 4 Transcription factors (TFs) strongly implicated in the regulation of HF core network modules.

From: Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

TFs Module BP P TF-Module KHFB HTraffic
      ITGB1
      FHL2
E2F-4:DP-2 13 Cell adhesion, signal transduction 0.04 CKM COL8A1
      CKM
      ITGA2
      ITGB1
      FHL2
E2F-1:DP-2 13 Cell adhesion, signal transduction 0.04 CKM COL8A1
      CKM
      ITGA2
      ITGB1
      FHL2
E2F-1:DP-1 13 Cell adhesion, signal transduction 0.04 CKM COL8A1
      CKM
      ITGA2
      ITGB1
    0.04 CKM FHL2
E2F-1 13 Cell adhesion, signal transduction    COL8A1
      CKM
      ITGA2
      PDGFRB
      ADAM15
E2F-1 16 Cell communication, phosporilation 0.02 IL6 IL6ST
      PDGFRA
      GRB2
  1. BP: Examples of GO biological process over-represented in a module (with P < 0.05 after adjusting for multiple-testing). P TF-Module : Probability value for the association TF-module (after correcting for multiple-testing). KHFB: Known HF biomarkers controlled by the TF within the specified module. HTraffic: examples of high-traffic proteins, including putative biomarkers, regulated by the specified TF.