Figure 2

Graphical Representation of Complexes. (A) Two alternate views of the STAT1 homodimer both of which would be considered to be formally correct under the mEPN scheme. (B) Visual representation of interferon-gamma receptor complex bound to IFNG. For membrane receptor complexes such this we have generally favoured showing the complexes spanning the plasma membrane (brown) with the receptor portion protruding into the extra-cellular space (grey) and with the adaptor molecules projecting into the cytoplasm (yellow). (C) The 26S proteasome has a barrel-like structure made up of 6 six concentric rings each composed of 7 proteasome subunits, capped with regulatory subunits at either end. We therefore chose to arrange the subunit in names in this manner so as to capture visually something of this arrangement. (D) Model of the transcription factor/coactivator complex that regulate genes associated with MHC class2 antigen presentation such as CD74. In this case transcription is thought to be regulated by two transcription factor complexes, CREB1 and one unknown factor which bind directly to four elements in the gene's promoter and transcription is initiated by a conformation change induced by the binding of CIITA. Here as in E interaction edges are used to denote a physical link between components of the complex. (E) DNA replication complex formed during S-phase. As complexes become large the use of the physical interaction edge becomes essential in defining not only which components make up the complex but where in the complex they reside. This arrangement also allows for the depiction of specific components of the complex to undergo a change in state or cause a change in another component (which may or may not be part of the same complex).