Figure 1

The process of the reconstruction of the key signal transduction pathways embedded in the global protein-protein interaction network of S. cerevisiae. From different types of available information such as different biochemical pathway databases, different textbooks, recent publications and reviews and genome annotations, a physical reconstruction of a protein-protein interaction network was designed and annotated so that each protein and their interactions include all information. The pathway map picture was taken from the KEGG database (www.genome.ad.jp) and SGD, Biogrid, Cytoscape and CellDesigner logos were taken from their respective websites.