Network of genes in the 17 modules reproducibly correlated with tumor grade. Nodes represent genes and edges represent co-expression between genes. Edges connecting genes in the same module are colored in dark grey, while edges connecting genes in different modules are colored in light grey. Genes in the same module are represented by nodes of the same shape. Genes belonging to multiple modules are represented by round nodes. The color scale bar shows the scale of p values for correlations between gene expression and tumor grade as calculated by the Jonckheere-Terpstra test. Modules are clustered into three connected components I, II, and III. Primary function annotations for each module are labeled in the figure.