Subset of the HIV-host interaction network. Red circles and grey squares correspond to HIV-1 (n = 19) and human proteins, respectively (n = 3,118). Human proteins that are hubs (degree ≥23) or bottlenecks (betweenness ≥2.43 × 10-04) are shown as green triangles (n = 69) and yellow triangles (n = 45), respectively. Human proteins that are hubs and bottlenecks are shown as blue triangles (n = 261). Pink edges correspond to interactions between HIV-1 and human proteins (n = 2588) whilst blue edges correspond to human-human interactions (n = 3800), where one of the proteins interacts with HIV-1. HIV-1 proteins are labelled.