Structural and functional characteristics of C-pairs of CT-PPI. (A) The distribution of the number of C-pairs in randomized networks (blue bars) and in real network (red bar). (B) Functional coherence fraction comparison among C-pairs, CT pairs and PPI pairs. Using a background of GO annotation, the significance on CT-PPI/CT is p < 0.0001 and CT-PPI/PPI p < 0.0303. Using narrow annotation, the significance on CT-PPI/CT is p < 2.8384E-027 and CT-PPI/PPI p < 1.8466E-07.