Figure 4

A strong impairment of protein diffusivity is required to maintain spatial anisotropies during apoptosis execution. (A) The end-to-end delays in achieving half maximal cleavage of effector caspase substrates has been calculated for the modelled HeLa cell scenario at impaired diffusion across 5 orders of magnitude. (B) End-to-end delays for the full spectrum of substrate cleavage across a continuous range of impaired diffusivities. (C-F) Temporal profiles of substrate cleavage at the near and far ends of the modelled cell for 10, 100, 1000, and 10000-fold impaired diffusivity.