Figure 2
From: microRNA evolution in a human transcription factor and microRNA regulatory network
Coevolutionary patterns of TFs and miRNAs. (A) For TF-miRNA regulatory pairs connected by transcriptional activation signals, TFs with a low evolutionary rate preferentially regulate miRNAs with a low evolutionary rate, and vice versa. (B) For TF-miRNA regulatory pairs connected by transcriptional repression signals, no difference was found between the evolutionary rates of miRNAs regulated by TFs with a low evolutionary rate and those with a high evolutionary rate.