Figure 5
From: Predicting functional associations from metabolism using bi-partite network algorithms
Performance comparison, incorporating metabolic constraints. The best local and global methods are compared with methods that use the knowledge that the network models steady-state metabolism. These methods predict synthetic lethal interactions based on decreases to a fitness function ("Scaled epistasis", ref. [10]) and based on correlations of steady-state fluxes sampled over feasible space ("Flux corrln.", ref. [2]). (A) ROC curve. (B) PR curve.