From: Predicting functional associations from metabolism using bi-partite network algorithms
Scores | Performance on 170 SL pairs (full network) | Performance on 69 SL pairs(reduced network) | Genes in full network, 283 GO terms (152-BP; 85-MF; 46-CC) | Genes in reduced network, 203 GO terms (110-BP; 60-MF; 33-CC) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | AUC (ROC) | F-Score (PR) | AUC (ROC) | F-Score (PR) | Total | BP | MF | CC | Total | BP | MF | CC |
Compartments | ||||||||||||
Shared Mets | 0.69 | 0.16 | 0.75 | 0.26 | 61 | 52 | 69 | 78 | 50 | 41 | 62 | 61 |
Shared Mets (low degree) | 0.67 | 0.15 | 0.76 | 0.27 | 65 | 64 | 61 | 74 | 55 | 58 | 45 | 61 |
Hypergeometric p-value | 0.69 | 0.21 | 0.76 | 0.43 | 72 | 64 | 79 | 85 | 63 | 55 | 75 | 67 |
Bayes Score | 0.70 | 0.21 | 0.76 | 0.43 | 72 | 64 | 79 | 83 | 63 | 55 | 75 | 67 |
Poisson Score | 0.70 | 0.20 | 0.76 | 0.40 | 72 | 64 | 79 | 85 | 60 | 52 | 73 | 64 |
Poisson Score (met. degree) | 0.70 | 0.21 | 0.79 | 0.47 | 81 | 73 | 94 | 83 | 74 | 65 | 90 | 73 |
Graph diffusion kernel score | 0.74 | 0.23 | 0.79 | 0.39 | 94 | 90 | 99 | 98 | 92 | 87 | 97 | 100 |
Graph diffusion kernel score (weighted edges) | 0.72 | 0.22 | 0.79 | 0.39 | 93 | 88 | 99 | 98 | 92 | 87 | 97 | 100 |
Flux Correlation | - | - | 0.87 | 0.49 | - | - | - | - | 64 | 66 | 53 | 73 |
Poisson Score (met. associations, deg.) | 0.70 | 0.21 | 0.79 | 0.47 | 81 | 73 | 93 | 83 | 74 | 65 | 92 | 70 |
Scaled epistasis | - | - | 0.54 | 0.08 | - | - | - | - | - | - | - | - |
No Compartments | ||||||||||||
Shared mets. | 0.68 | 0.09 | 0.73 | 0.22 | 55 | 47 | 69 | 54 | 49 | 38 | 67 | 52 |
Shared mets. (low deg. mets.) | 0.66 | 0.18 | 0.73 | 0.26 | 71 | 72 | 76 | 54 | 64 | 67 | 62 | 58 |
Hypergeometric P-value | 0.69 | 0.13 | 0.76 | 0.39 | 66 | 59 | 78 | 65 | 57 | 45 | 73 | 67 |
Bayes Score | 0.69 | 0.13 | 0.76 | 0.39 | 66 | 59 | 78 | 65 | 57 | 45 | 73 | 67 |
Poisson Score | 0.69 | 0.12 | 0.75 | 0.33 | 64 | 57 | 76 | 65 | 56 | 44 | 73 | 64 |
Poisson Score (met. degree) | 0.72 | 0.31 | 0.80 | 0.49 | 78 | 72 | 93 | 72 | 75 | 65 | 92 | 76 |
Graph diffusion kernel score | 0.72 | 0.26 | 0.79 | 0.38 | 94 | 91 | 99 | 93 | 91 | 85 | 98 | 94 |
Graph diffusion kernel score (weighted edges) | 0.70 | 0.25 | 0.79 | 0.4 | 93 | 90 | 99 | 93 | 89 | 86 | 93 | 88 |
Poisson score(met. associations, deg.) | 0.72 | 0.30 | 0.79 | 0.48 | 80 | 74 | 93 | 72 | 75 | 65 | 90 | 79 |