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Table 1 Clusters of KEGG AD pathway (hsa05010) in different brain regions

From: Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

Region Pathway ID Size Edge Node P-value Description
EC hsa00190 137 7 12 0.115269 Oxidative phosphorylation
  hsa04110 119 344 101 1.000000 Cell cycle
  hsa04115 69 72 46 0.146277 p53 signaling pathway
  hsa05012 136 25 26 0.130562 Parkinson's disease
  hsa05040 32 27 21 0.207717 Huntington's disease
  hsa05050 15 10 11 0.213708 Dentatorubropallidoluysian atrophy (DRPLA)
HIP hsa04080 302 106 128 0.815693 Neuroactive ligand-receptor interaction
  hsa04115 69 72 46 0.362224 p53 signaling pathway
  hsa04720 72 37 32 0.117635 Long-term potentiation
  hsa04730 75 41 38 0.025842 Long-term depression
  hsa05050 15 10 11 0.347488 Dentatorubropallidoluysian atrophy (DRPLA)
MTG hsa04360 129 100 72 0.094750 Axon guidance
  hsa04370 74 54 41 0.672299 VEGF signaling pathway
  hsa05014 56 35 28 0.853204 Amyotrophic lateral sclerosis (ALS)
  hsa05040 32 27 21 0.707504 Huntington's disease
  hsa05050 15 10 11 0.719474 Dentatorubropallidoluysian atrophy (DRPLA)
PC hsa04210 89 156 72 0.195914 Apoptosis
  hsa04730 75 41 38 0.880031 Long-term depression
  hsa05040 32 27 21 0.084885 Huntington's disease
  hsa05050 15 10 11 0.056018 Dentatorubropallidoluysian atrophy (DRPLA)
SFG hsa04010 274 403 188 0.082078 MAPK signaling pathway
  hsa04360 129 100 72 0.094750 Axon guidance
  hsa04370 74 54 41 0.344348 VEGF signaling pathway
  hsa05014 56 35 28 0.257644 Amyotrophic lateral sclerosis (ALS)
  hsa05040 32 27 21 0.505385 Huntington's disease
VCX hsa00190 137 7 12 0.197734 Oxidative phosphorylation
  hsa05012 136 25 26 0.291280 Parkinson's disease
  hsa05040 32 27 21 0.518223 Huntington's disease
  hsa05050 15 10 11 0.516887 Dentatorubropallidoluysian atrophy (DRPLA)
  1. “Size” is the number of genes contained in KEGG gene sets. “Edge” and “Node” represent the number of edges and nodes of these pathways in our protein-protein interaction network with gene expression information. “P-value” gives the p-value of dysregulation score of every pathway in the cluster. “Description” gives the pathway name.