Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

BMC Systems Biology

Table 1 Clusters of KEGG AD pathway (hsa05010) in different brain regions

Region	Pathway ID	Size	Edge	Node	P-value	Description
EC	hsa00190	137	7	12	0.115269	Oxidative phosphorylation
	hsa04110	119	344	101	1.000000	Cell cycle
	hsa04115	69	72	46	0.146277	p53 signaling pathway
	hsa05012	136	25	26	0.130562	Parkinson's disease
	hsa05040	32	27	21	0.207717	Huntington's disease
	hsa05050	15	10	11	0.213708	Dentatorubropallidoluysian atrophy (DRPLA)
HIP	hsa04080	302	106	128	0.815693	Neuroactive ligand-receptor interaction
	hsa04115	69	72	46	0.362224	p53 signaling pathway
	hsa04720	72	37	32	0.117635	Long-term potentiation
	hsa04730	75	41	38	0.025842	Long-term depression
	hsa05050	15	10	11	0.347488	Dentatorubropallidoluysian atrophy (DRPLA)
MTG	hsa04360	129	100	72	0.094750	Axon guidance
	hsa04370	74	54	41	0.672299	VEGF signaling pathway
	hsa05014	56	35	28	0.853204	Amyotrophic lateral sclerosis (ALS)
	hsa05040	32	27	21	0.707504	Huntington's disease
	hsa05050	15	10	11	0.719474	Dentatorubropallidoluysian atrophy (DRPLA)
PC	hsa04210	89	156	72	0.195914	Apoptosis
	hsa04730	75	41	38	0.880031	Long-term depression
	hsa05040	32	27	21	0.084885	Huntington's disease
	hsa05050	15	10	11	0.056018	Dentatorubropallidoluysian atrophy (DRPLA)
SFG	hsa04010	274	403	188	0.082078	MAPK signaling pathway
	hsa04360	129	100	72	0.094750	Axon guidance
	hsa04370	74	54	41	0.344348	VEGF signaling pathway
	hsa05014	56	35	28	0.257644	Amyotrophic lateral sclerosis (ALS)
	hsa05040	32	27	21	0.505385	Huntington's disease
VCX	hsa00190	137	7	12	0.197734	Oxidative phosphorylation
	hsa05012	136	25	26	0.291280	Parkinson's disease
	hsa05040	32	27	21	0.518223	Huntington's disease
	hsa05050	15	10	11	0.516887	Dentatorubropallidoluysian atrophy (DRPLA)

“Size” is the number of genes contained in KEGG gene sets. “Edge” and “Node” represent the number of edges and nodes of these pathways in our protein-protein interaction network with gene expression information. “P-value” gives the p-value of dysregulation score of every pathway in the cluster. “Description” gives the pathway name.

ISSN: 1752-0509