Table 1 Algorithm: Pairwise Gene Hierarchy Criterion

Input:

all pairwise gene candidates GPs;

initial MI threshold MIth = MI's centroid;

initial CC threshold CCth = CC's centroid;

increments δ_mi, δ_cc for MI and CC.

Output:

   classified APGs, UPGs and QPGs.

while count(GPs)>0 do

1. construct APGs, QPGs using initial MIth, CCth and P-value;

2. group the others into UPGs;

if (APGs' undersized) && count(QPGs)>0 then do

MIth=MIth-δ_mi & CCth=CCth-δ_cc;

continue Step 1 for QPGs & obtain Δ_APGs and Δ_UPGs;

APG=APGs+Δ_APGs & UPGs=UPGs-Δ_UPGs.

   elseif(APGs' oversized) then do

MIth=MIth-δ_mi & CCth=CCth+δ_cc;

continue Step 1 for APGs & obtain Δ_APGs and Δ_UPGs;

APG=APGs-Δ_APGs & UPGs=UPGs+Δ_APGs.

   endif

end