Figure 2

Inferring new TR interactions. From the existing TR interaction data, genes a, b, c, and d are known to be target genes of a TF, and A, B, C, and D stands for their proteins. From the PPI network and GE, if we observe that the proteins A, B, C, D and an additional protein E interact intensively one another, and that their coding genes a, b, c, d and e express co-ordinately, we can predict that the TF also regulate e under the same condition. The reason is that E is so similar to the co-regulated protein group of A, B, C, D at the levels gene expression and protein-protein interaction that it can be inferred that e also has TR interactions associated with TF just as a, b, c and d do, although the known TR dataset does not indicate this.