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Figure 5 | BMC Systems Biology

Figure 5

From: Parameter optimization by using differential elimination: a general approach for introducing constraints into objective functions

Figure 5

Model 2: cascade reaction The molecular cascade reaction of four molecules is schematically shown (A). According to the kinetics in the model (see details in Methods), a reference curve of one variable, x1, was generated for 0t1 with intervals of 0.01, under the following conditions: x1(0) = 10.0, x2(0) = 130.0, x3(0) =80.0, x4(0)=170.0, k21=5.0, k31=7.0, k41=11.0, k p 2 = 3.0, k p 3=4.0, k p 4=10.0, k e 1=5.0 and k e 2=3.0 (B).

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