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Table 1 Summary of results for the basic model

From: The coupling of pathways and processes through shared components

Scenario Result
Changing the rate production of the shared Component, X. At steady state, "ultrasensitivity" may be observed in the response of the lower affinity component, and of free X. When one examines the dynamics of the response of the two pathways, the relative timescales of the interactions are important. Depending on this, the dynamics may mirror the steady state response; alternatively, an adaptive response may be observed in the low affinity component.
Changing the rate of production of A and B. The two pathways may inhibit one another, with the high affinity component having a greater inhibitory effect. Depending on the timescales of the interactions, the dynamics may either mirror the steady state response, or result in an adaptive response in the lower affinity pathway.
  1. We consider the case where the shared component, X, binds with high affinity to component A, forming the complex AX, and with low affinity to component B, forming the complex BX.