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Table 2 Comparison of the areas with respect to different time ranges in Figure 9

From: An Integrated Mathematical Model of Thrombin-, Histamine-and VEGF-Mediated Signalling in Endothelial Permeability

MLC activation curve

Area under MLC activation curve with respect to different time range (time unit:min)

 

0-10

10-20

20-30

30-40

40-50

50-60

60-70

70-80

Curve 1:Thrombin + VEGF induced activation

5.0

6.2

6.7

5.1

3.4

2.4

1.9

1.4

Curve 2:VEGF-mediated activation

4.1

3.5

2.9

3.2

3.3

3.4

3.4

3.1

Curve 3:Thrombin-mediated activation

4.0

2.6

2.0

1.1

0.05

0.5

0.4

0.3

Simple sum of curve 2 and 3

8.1

6.1

4.9

4.3

3.35

3.9

3.8

3.4

Area difference between curve 1 and simple sum of curve 2 and 3

-3.1

0.1

1.8

0.7

0.05

-1.5

-1.9

-2.0

  1. Comparison of the areas under the thrombin and VEGF induced MLC activation curve with those of thrombin-induced and VEGF-induced MLC activation curves with respect to different time ranges in Figure 9.