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Table 1 The inferred recurrent regions of CNV in the four breast cancer datasets.

From: Inferring causal genomic alterations in breast cancer using gene expression data

Cytoband Location Chr Start(Mb) End (Mb) Size (Mb) Gain/Loss Important genes
chr3q26.31-q27.1 3 173.95 185.91 11.96 G ECT2, PIK3CA, PSMD2, CLCN2, POLR2H
chr4p16.3 4 0.69 1.95 1.26 G CTBP1, TACC3
chr5q35.2-q35.4 5 173.41 179.09 5.69 G GRK6, DDX41
chr8p21.2-p12 8 23.59 30.70 7.11 L CLU
chr8q24.3 8 143.54 146.25 2.71 G NRBP2
chr11q13.1-q13.4 11 64.54 71.59 7.05 G MAP3K11, ADRBK1, RPS6KB2, LRP5, CPT1A
chr12q24.23-q24.33 12 120.70 122.32 1.62 G  
chr16p13.4 16 2.02 2.66 0.64 G DCI, PDPK1
chr16q12.2-q22.1 16 54.25 69.11 14.87 G POLR2C, KIFC3, CSNK2A2, GOT2, CDH5, PSKH1, PSMB10, VPS4A,
chr16q22.3-q24.3 16 82.56 88.62 6.06 G GALNS
chr20q11.1-q11.23 20 28.24 36.99 8.75 G TPX2, APBA2BP, E2F1, EIF2S2, AHCY, GSS, PROCR, RBM39, SCAND1, DLGAP4, GHRH, BLCAP
chr20q13.12-q13.13 20 44.43 49.01 4.58 G ARFGEF2, CSE1L
  1. The important genes include known oncogenes, known tumor suppressors, and the genes that, when silenced, reduced cell viability by more than 50% based on our siRNA experiments.