Figure 6
From: A retrosynthetic biology approach to metabolic pathway design for therapeutic production
Retrosynthetic maps for the production in E. coli of A) penicillin G and B) cephalosporin. Compounds in gray are endogenous to the chassis organism (E. coli); enzymatic reactions are represented as circles; branching compounds, which can be produced by more than one biochemical transformation, are (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, L-2-aminoadipate-6-semialdehyde; the target compound is at the bottom of the plot.