Biological interaction networks are conserved at the module level

BMC Systems Biology

Table 1 Conservation statistics between S. cerevisiae and S. pombe

Baseline	Previous explanations			Module based explanations
	Hubs	Complexes	Molecular function	WMI	WMI -no hubs	WMI ext.
18.11%	26%	26%/35%	26%	46.54%	42.87%	49.66%

Conservation rates for S. pombe with respect to S. cerevisiae are based on the integrated networks for the following categories: Baseline: the entire networks; Hubs: highest rate reported for any bin based on node degree; Complexes: complexes as defined by the Gavin and Krogran studies [13, 14]; Molecular function: highest rate reported for interactions with any GO molecular function; WMI: Within-Module Interactions; WMI - no hubs: WMI excluding interactions with hubs; Extended WMI: extended module interactions. See text for further details.

ISSN: 1752-0509