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Table 4 Top ranking miRNA clusters with interconnected target sets

From: MicroRNAs coordinately regulate protein complexes

miRNA cluster15,* # targ Ppis [#| P-value] Ppis [miR-miR] [# |P-value]
hsa-miR-3671-101 116 94 0.1294 94 0
hsa-let-7a-7b 120 48 0.1748 48 0
hsa-miR-1912-1264 49 24 0.3224 24 0
hsa-miR-214-199a 69 22 0.3222 22 0
hsa-miR-296-298 52 24 0.3324 24 0
hsa-miR-105-767 58 18 0.3418 18 0
hsa-miR-34b-34c 43 22 0.3522 22 0
hsa-miR-3677-940 55 18 0.3618 18 0
hsa-miR-1914-647 38 20 0.3720 20 0
hsa-miR-599-875 23 6 0.536 6 0
hsa-miR-16-15a 172 172 0.12172 172 0
hsa-miR-15b-16 172 172 0.15172 172 0
hsa-miR-181c-181d 160 142 0.21142 142 0
hsa-miR-195-497 172 172 0.15172 172 0
hsa-miR-181a-181b 160 142 0.19142 142 0
hsa-miR-181b-181a 160 142 0.18142 142 0.01
hsa-miR-30e-30c 183 144 0.2144 144 0.01
hsa-miR-513c-513b 125 142 0.21142 142 0.01
hsa-miR-23b-24 305 584 0.02234 234 0.01
hsa-miR-363-106a 341 550 0.29823 823 0.01
hsa-miR-200c-141 246 392 0.02112 112 0.01
hsa-miR-30b-30d 183 144 0.2144 144 0.01
hsa-miR-519a-1283 298 702 0.02258 258 0.01
hsa-miR-24-23a 305 584 0.03234 234 0.02
hsa-miR-522-1283 323 864 0.02377 377 0.02
hsa-miR-25-106b 233 236 0.22224 224 0.02
hsa-miR-301b-130b 123 86 0.3486 86 0.03
hsa-miR-182-183 218 288 0.15196 196 0.03
hsa-miR-17-92a 341 550 0.28607 607 0.03
hsa-miR-133a-1 189 262 0.0574 74 0.03
hsa-miR-545-374a 180 212 0.0862 62 0.04
hsa-miR-206-133b 189 262 0.0774 74 0.04
hsa-miR-29a-29b 126 64 0.3864 64 0.05
hsa-miR-513a-508 242 256 0.0559 59 0.05
hsa-miR-513a-507 242 256 0.0559 59 0.05
  1. *miRNA cluster is termed in the following way: miR-first_miRNA-last_miRNA. For instance, miR-17-92a cluster is consisted of six miRNAs, miR-17 is the first miRNA in the cluster and miR-92a is the last miRNA in the cluster.
  2. Interconnectivity of the target sets was evaluated as: (1) Number of interactions in the union target set and (2) Number of interactions between target sets of all distinct miRNA pairs in a cluster (ppis [miR-miR]). The P-values were estimated by comparing the observed value with 1,000 randomly sampled target sets of equal size. The results for all clusters are shown in Additional file 7, Table S7 online.