MicroRNAs coordinately regulate protein complexes

BMC Systems Biology

Table 4 Top ranking miRNA clusters with interconnected target sets

miRNA cluster^15,*	# targ	Ppis [#\| P-value]		Ppis [miR-miR] [# \|P-value]
hsa-miR-3671-101	116	94	0.1294	94	0
hsa-let-7a-7b	120	48	0.1748	48	0
hsa-miR-1912-1264	49	24	0.3224	24	0
hsa-miR-214-199a	69	22	0.3222	22	0
hsa-miR-296-298	52	24	0.3324	24	0
hsa-miR-105-767	58	18	0.3418	18	0
hsa-miR-34b-34c	43	22	0.3522	22	0
hsa-miR-3677-940	55	18	0.3618	18	0
hsa-miR-1914-647	38	20	0.3720	20	0
hsa-miR-599-875	23	6	0.536	6	0
hsa-miR-16-15a	172	172	0.12172	172	0
hsa-miR-15b-16	172	172	0.15172	172	0
hsa-miR-181c-181d	160	142	0.21142	142	0
hsa-miR-195-497	172	172	0.15172	172	0
hsa-miR-181a-181b	160	142	0.19142	142	0
hsa-miR-181b-181a	160	142	0.18142	142	0.01
hsa-miR-30e-30c	183	144	0.2144	144	0.01
hsa-miR-513c-513b	125	142	0.21142	142	0.01
hsa-miR-23b-24	305	584	0.02234	234	0.01
hsa-miR-363-106a	341	550	0.29823	823	0.01
hsa-miR-200c-141	246	392	0.02112	112	0.01
hsa-miR-30b-30d	183	144	0.2144	144	0.01
hsa-miR-519a-1283	298	702	0.02258	258	0.01
hsa-miR-24-23a	305	584	0.03234	234	0.02
hsa-miR-522-1283	323	864	0.02377	377	0.02
hsa-miR-25-106b	233	236	0.22224	224	0.02
hsa-miR-301b-130b	123	86	0.3486	86	0.03
hsa-miR-182-183	218	288	0.15196	196	0.03
hsa-miR-17-92a	341	550	0.28607	607	0.03
hsa-miR-133a-1	189	262	0.0574	74	0.03
hsa-miR-545-374a	180	212	0.0862	62	0.04
hsa-miR-206-133b	189	262	0.0774	74	0.04
hsa-miR-29a-29b	126	64	0.3864	64	0.05
hsa-miR-513a-508	242	256	0.0559	59	0.05
hsa-miR-513a-507	242	256	0.0559	59	0.05

*miRNA cluster is termed in the following way: miR-first_miRNA-last_miRNA. For instance, miR-17-92a cluster is consisted of six miRNAs, miR-17 is the first miRNA in the cluster and miR-92a is the last miRNA in the cluster.
Interconnectivity of the target sets was evaluated as: (1) Number of interactions in the union target set and (2) Number of interactions between target sets of all distinct miRNA pairs in a cluster (ppis [miR-miR]). The P-values were estimated by comparing the observed value with 1,000 randomly sampled target sets of equal size. The results for all clusters are shown in Additional file 7, Table S7 online.

ISSN: 1752-0509