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Figure 2 | BMC Systems Biology

Figure 2

From: TIGER: Toolbox for integrating genome-scale metabolic models, expression data, and transcriptional regulatory networks

Figure 2

The gene-protein-reaction relationship. Boolean logic is used to describe gene-protein-reaction (GPR) relationships of varying complexity. Reactions can carry flux if and only if a correct combination of genes is expressed. Reaction 1 is catalyzed by a single gene product (reaction 1 ⇔ gene a). Reactions 2 and 3 are both catalyzed by the product of gene b (reaction 1 ⇔ gene b, reaction 2 ⇔ gene b). Genes c and d produce subunits of an enzymatic complex; both proteins are required for reaction 4 to carry flux (reaction 4 ⇔ gene c and gene d). Genes e and f encode isozymes. Either enzyme can catalyze reaction 5 (reaction 5 ⇔ gene e or gene f ).

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BMC Systems Biology

ISSN: 1752-0509

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