Figure 4
From: The logic of kinetic regulation in the thioredoxin system
Ultrasensitive changes in the steady state concentrations of the redox couples in the thioredoxin and Tpx redox cycles are dependent on the kinetics of the Tpx redox cycle. In each of these simulations, the ratio of the second order rate constants for Tpx oxidation and reduction (i.e. kH2O2/ktrxsh, Table 1) were varied from 0.015 (black, •••), 0.05 (red, ---), 0.10 (blue, solid line) to 1.00 (green, -•-) and the effect on the steady state concentrations of reduced thioredoxin (TrxSH), oxidized thioredoxin (TrxSS), reduced Tpx (TpxSH) and oxidized Tpx (TpxSS) monitored. Parameters were as in Table 2, except where indicated otherwise. This figure was generated using 'Logic_Figure 2_and_Figure 4.psc' (Additional file 1). A SBML version of this model ('Logic_Figure 2_and_Figure 4.xml') is available as Additional file 5.