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Figure 4 | BMC Systems Biology

Figure 4

From: Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity

Figure 4

Distribution of the size of off-target effects in the n = 3 network. Histograms of the size of off-target effects in n = 3 network (Figure 3D) are plotted for two different parameter spaces. The y-axis on each plot represents the proportion of all parameter sets that produced off-target effects in 5000 randomly selected parameter sets. The x-axis on each plot represents the size of an off-target effect in cycle 2 as a proportion of Y2T such that each value indicates a response that was at least as big as the given value but less than the next sequential value. For example, a value of .30 indicates that the magnitude of the response was greater than or equal to .30 but less than 0.40. (A) The majority of off-target effects in the original n = 3 parameter space (depicted in Figure 3H) were less than 0.30. (B) In contrast, the distribution of the size of off-target effects in the restricted n = 3 parameter space (depicted in Figure 3I) was more uniform.

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