Figure 4
Predicted time course profiles of arsenicals in human hepatocytes using two TK model formulations. The top row shows estimates from the TK model presented here, while the bottom row shows estimates from the TK model formulated using the Easterling et al. [34] approach. The left column shows intracellular levels of iAsIII, total MMA, and total DMA, while the right column shows corresponding extracellular levels. Experimental data are from Styblo et al. [51] (exposures to 0.1 μM arsenic for 2 days)