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Table 2 Comparison between experimental data and model simulations for growth on eleven different carbon sources.

From: An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92

Carbon Source

Experimental

Computational

Comments

Gluconate

Yes (0.27)

Yes

 
  

Without citrate: 0.27

 
  

With citrate: 0.28

 

Glucose

Yes (0.29)

Yes

 
  

Without citrate: 0.28

 
  

With citrate: 0.28

 

Glycerol

No

Yes

Model suggests glycerol can enter central metabolism indirectly through fatty acid biosynthesis and degradation pathways, thereby permitting slow growth

Acetate

Yes (0.14)

Yes

 

Citrate

Yes (0.086)

Yes

 

Lactate

Yes (0.12)

Yes

 

Xylose

Yes (0.20)

Yes

 

Ribose

Yes (0.17)

Yes

 

Galactose

Yes (0.16)

Yes

 

Maltose

Yes (0.27)

Yes

 

Arabinose

Yes (0.28)

Yes

 
  1. Values in parentheses in the Experimental column are the measured growth rates performed as part of this study. Values in parentheses in the Computational column indicate model-predicted growth rates in BCS defined media with or without citrate and with glucose or gluconate as the principal carbon source.
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BMC Systems Biology

ISSN: 1752-0509

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