Figure 5

PIN provides higher coverage of authentic interactions and increased rejection of spurious interactions. A) PIN (RED) permits Identification of more positive reference set (PRS) membrane interactions than the Hypergeometric (blue) and BIOGRID (green) networks. B) PIN rejects Identification of slightly more random reference set (RRS) membrane interactions than the Hypergeometric and BIOGRID networks. C) PIN permits Identification of more positive reference set (PRS) interactions than the Hypergeometric model and BIOGRID networks. D) PIN rejects identification of more random reference set (RRS) interactions than the Hypergeometric and BIOGRID networks.