Table 3 Dynamic variables and constants of basal cyclic nucleotide signaling.

4 μM

Basal levels

[14]

0.4 μM

Basal levels

[14]

0.05 mg/l

Model-based simulation

This study

Experimentally: 63.46 mg/l

2.3 mg/l

Model-based simulation

This study

Experimentally: 225 mg/l

1 mg/l

Model-based simulation

This study

Experimentally: 1359 mg/l

(63.46 -x₃) mg/l

(225 - x₄) mg/l

(1359 - x₅) mg/l

μM; simulated

μM; simulated

120 μmol/min/mg

cAMP turnover

[2, 16]

50 μM

cAMP turnover

[2, 16]

3 μmol/min/mg

cAMP turnover

[2, 16]

0.2 μM

cAMP turnover

[2, 16]

120 μmol/min/mg

cGMP turnover

[2, 16]

35 μM

cGMP turnover

[2, 16]

0.3 μmol/min/mg

cGMP turnover

[2, 16]

0.02 μM

cGMP turnover

[2, 16]

5 μmol/min/mg

cGMP turnover

[2, 16]

5 μM

cGMP turnover

[2, 16]

8 μmol/min

Basal influx of cAMP

[17–19]

1 μmol/min

Basal influx of cGMP

[64, 65]

This study

k₁₃-k₁₈: = 0

This study

for simulation of

This study

basal levels

This study

(resting conditions)

This study

This study

2

Hill coefficient

[15, 16]