Inferring pleiotropy by network analysis: linked diseases in the human PPI network

Nguyen, Thanh-Phuong; Liu, Wei-chung; Jordán, Ferenc

doi:10.1186/1752-0509-5-179

BMC Systems Biology

Table 4 Centrality ranks in the HO network.

From: Inferring pleiotropy by network analysis: linked diseases in the human PPI network

	nD		nCC		nBC		TI³		TO³_0.01		TO³_0.005
P62993	38.17	P62993	50.40	P62993	47.09	P62993	307.09	P62993	6637	P62993	14457
P63104	24.30	P12931	46.24	P63104	32.23	P63104	215.63	P63104	6333	P63104	14457
P06241	19.89	P21333	45.68	P17252	17.01	P06241	134.44	P12931	5744	P49407	14244
P12931	17.99	P07355	45.61	P12931	16.91	P12931	117.55	P06241	5056	P17252	12792
P17252	12.67	Q13813	45.61	P49407	16.71	P49407	108.09	P17252	3089	P12931	12396
P49407	12.67	P22681	45.42	P06241	16.12	P17252	106.48	P28482	2667	P06241	10742
P28482	11.00	P00533	45.40	P28482	13.75	P28482	88.40	P49407	1797	P28482	10633
P41240	3.44	P61978	44.96	Q5JY77	4.04	Q5JY77	26.59	P41240	1035	P41240	4498
Q5JY77	2.69	Q07889	44.56	O14908	3.32	O14908	22.70	P07550	244	O14908	3414
O14908	2.58	Q13322	44.56	P41240	2.03	P41240	19.48	Q14232	242	Q5JY77	3363
Q14232	0.97	P06241	44.20	P07550	1.51	Q14232	8.44	P08913	215	P04629	3281
P54646	0.57	P11142	44.16	Q14232	0.94	P54646	5.41	P14866	215	P08588	3281
P00533	0.34	P07900	44.01	P08588	0.73	P07550	1.40	P18089	215	P98164	3281
P07550	0.34	P62988	44.00	P54646	0.69	P07900	1.37	P18825	215	P07550	2835
P07900	0.34	P63104	43.46	P21333	0.59	P00533	1.32	P81605	215	P08069	1976
P22681	0.34	P29353	43.38	P07900	0.57	P61978	1.28	O14908	208	O00222	1872
P29353	0.34	P35568	43.32	P07355	0.51	P22681	1.28	Q92793	189	O15534	1872
P61978	0.34	P00519	43.29	Q13813	0.51	P29353	1.25	P23508	186	O43193	1872
O14939	0.29	P56945	43.29	P61978	0.51	P21333	1.19	P05198	185	O43504	1872
P04049	0.29	P28482	42.94	Q9UQ35	0.48	P07355	1.18	P13667	180	O60518	1872
P06213	0.29	O43707	42.74	P00533	0.47	Q13813	1.18	P20042	180	O60925	1872
P07355	0.29	P11274	42.74	O43707	0.46	P04049	1.12	P49703	180	O75665	1872
P21333	0.29	P02545	42.47	P11274	0.46	Q02156	1.12	P49770	180	O95295	1872
P49023	0.29	P05783	42.47	P22681	0.46	Q05513	1.12	P52565	180	P08173	1872
P98082	0.29	Q16658	42.47	P04629	0.46	Q07889	1.11	Q13144	180	P08912	1872
Q02156	0.29	P17252	42.45	P23458	0.41	Q13322	1.11	Q9BYD3	180	P11229	1872
Q05513	0.29	P23458	42.45	P11142	0.39	P06213	1.06	Q9NR50	180	P20309	1872
Q07889	0.29	P04049	42.41	Q7KZI7	0.39	P08588	1.05	Q5JY77	168	P21452	1872
Q13322	0.29	Q02156	42.41	P30556	0.39	P49023	1.03	O00418	165	P25025	1872
Q13813	0.29	Q05513	42.41	Q07889	0.37	O14939	1.02	O00763	165	P25103	1872

The rank of the most central 30 nodes in the HO network, based on the six importance indices analyzed.

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ISSN: 1752-0509

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