index
|
driver type
|
drivers
|
reg
|
sign
|
N
|
index
|
driver type
|
drivers
|
reg
|
sign
|
N
|
---|
1
|
intra CNV
|
seg 30 (chr 6p)
|
NA
|
+
|
84
|
44
|
inter CNV
|
seg 18 (chr 3p)
|
ZIC1,MITF
|
+
|
118
|
2
|
intra CNV
|
seg 54 (chr 12q)
|
NA
|
+
|
77
|
45
|
inter CNV
|
seg 31 (chr 6q)
|
TBP,MYB,HDAC2
|
+
|
77
|
3
|
intra CNV
|
seg 1 (chr 1p)
|
NA
|
+
|
74
|
46
|
inter CNV
|
seg 84 (chr 22q)
|
SREBF2,EP300
|
+
|
49
|
4
|
intra CNV
|
seg 57 (chr 14q)
|
NA
|
+
|
62
|
47
|
inter CNV
|
seg 30 (chr 6p)
|
E2F3,NFYA,SRF
|
+
|
31
|
5
|
intra CNV
|
seg 69 (chr 17q)
|
NA
|
+
|
62
|
48
|
inter CNV
|
seg 42 (chr 10q)
|
TCF7L2
|
+
|
30
|
6
|
intra CNV
|
seg 11 (chr 2p)
|
NA
|
+
|
58
|
49
|
inter CNV
|
seg 55 (chr 12q)
|
NR2C1,NFYB
|
+
|
22
|
7
|
intra CNV
|
seg 42 (chr 10q)
|
NA
|
+
|
55
|
50
|
inter CNV
|
seg 19 (chr 3q)
|
ZNF148
|
+
|
22
|
8
|
intra CNV
|
seg 3 (chr 1p)
|
NA
|
+
|
53
|
51
|
inter CNV
|
seg 63 (chr 16pq)
|
NFATC3,RBL2
|
+
|
21
|
9
|
intra CNV
|
seg 37 (chr 8q)
|
NA
|
+
|
53
|
52
|
inter CNV
|
seg 69 (chr 17q)
|
SPOP,NME2,POLG2
|
+
|
20
|
10
|
intra CNV
|
seg 59 (chr 14q)
|
NA
|
+
|
53
|
53
|
inter CNV
|
seg 42 (chr 10q)
|
NFKB2
|
+
|
19
|
11
|
intra CNV
|
seg 16 (chr 3p)
|
NA
|
+
|
49
|
54
|
inter CNV
|
seg 16 (chr 3p)
|
UBP1
|
+
|
18
|
12
|
intra CNV
|
seg 63 (chr 16pq)
|
NA
|
+
|
49
|
55
|
inter CNV
|
seg 83 (chr 22q)
|
EWSR1
|
+
|
17
|
13
|
intra CNV
|
seg 33 (chr 7q)
|
NA
|
+
|
47
|
56
|
inter CNV
|
seg 57 (chr 14q)
|
APEX1
|
+
|
16
|
14
|
intra CNV
|
seg 84 (chr 22q)
|
NA
|
+
|
47
|
57
|
inter CNV
|
seg 16 (chr 3p)
|
RPA2,EIF2C1
|
+
|
15
|
15
|
intra CNV
|
seg 55 (chr 12q)
|
NA
|
+
|
44
|
58
|
inter CNV
|
seg 19 (chr 3q)
|
CNBP
|
+
|
15
|
16
|
intra CNV
|
seg 51 (chr 11q)
|
NA
|
+
|
43
|
59
|
inter CNV
|
seg 51 (chr 11q)
|
RICS
|
+
|
14
|
17
|
intra CNV
|
seg 2 (chr 1p)
|
NA
|
+
|
42
|
60
|
inter CNV
|
seg 56 (chr 13q)
|
GTF3A
|
+
|
13
|
18
|
intra CNV
|
seg 73 (chr 19p)
|
NA
|
+
|
42
|
61
|
inter CNV
|
seg 4 (chr 1q)
|
RUNX3
|
+
|
10
|
19
|
intra CNV
|
seg 50 (chr 11q)
|
NA
|
+
|
40
|
62
|
mutation
|
APC
|
NA
|
+
|
136
|
20
|
intra CNV
|
seg 68 (chr 17q)
|
NA
|
+
|
39
|
63
|
mutation
|
APC
|
NA
|
-
|
56
|
21
|
intra CNV
|
seg 65 (chr 17p)
|
NA
|
+
|
37
|
64
|
mutation
|
PIK3CA
|
NA
|
+
|
50
|
22
|
intra CNV
|
seg 32 (chr 7p)
|
NA
|
+
|
36
|
65
|
mutation
|
CDKN2A
|
NA
|
-
|
43
|
23
|
intra CNV
|
seg 35 (chr 7q)
|
NA
|
+
|
35
|
66
|
mutation
|
TP53
|
NA
|
-
|
35
|
24
|
intra CNV
|
seg 31 (chr 6q)
|
NA
|
+
|
33
|
67
|
mutation
|
BRAF
|
NA
|
-
|
34
|
25
|
intra CNV
|
seg 19 (chr 3q)
|
NA
|
+
|
32
|
68
|
mutation
|
TP53
|
NA
|
+
|
33
|
26
|
intra CNV
|
seg 18 (chr 3p)
|
NA
|
+
|
30
|
69
|
mutation
|
CDKN2A
|
NA
|
+
|
32
|
27
|
intra CNV
|
seg 9 (chr 1q)
|
NA
|
+
|
29
|
70
|
mutation
|
KRAS
|
NA
|
+
|
25
|
28
|
intra CNV
|
seg 22 (chr 4p)
|
NA
|
+
|
29
|
71
|
mutation
|
PTEN
|
NA
|
+
|
20
|
29
|
intra CNV
|
seg 62 (chr 15q)
|
NA
|
+
|
29
|
72
|
mutation
|
KRAS
|
NA
|
-
|
16
|
30
|
intra CNV
|
seg 41 (chr 9q)
|
NA
|
+
|
28
|
73
|
mutation
|
BRAF
|
NA
|
+
|
16
|
31
|
intra CNV
|
seg 49 (chr 11q)
|
NA
|
+
|
28
|
74
|
mutation
|
PIK3CA
|
NA
|
-
|
13
|
32
|
intra CNV
|
seg 56 (chr 13q)
|
NA
|
+
|
28
|
75
|
mutation
|
PTEN
|
NA
|
-
|
13
|
33
|
intra CNV
|
seg 60 (chr 15q)
|
NA
|
+
|
28
|
76
|
methylation
|
PAX8
|
NA
|
-
|
61
|
34
|
intra CNV
|
seg 44 (chr 11p)
|
NA
|
+
|
27
|
77
|
methylation
|
BCR
|
NA
|
-
|
58
|
35
|
intra CNV
|
seg 61 (chr 15q)
|
NA
|
+
|
26
|
78
|
methylation
|
HOXC13
|
NA
|
-
|
19
|
36
|
intra CNV
|
seg 80 (chr 21q)
|
NA
|
+
|
24
|
79
|
methylation
|
CCND1,PPARG
|
NA
|
-
|
13
|
37
|
intra CNV
|
seg 36 (chr 8p)
|
NA
|
+
|
23
|
80
|
methylation
|
COL5A1
|
NA
|
-
|
10
|
38
|
intra CNV
|
seg 27 (chr 5q)
|
NA
|
+
|
22
|
81
|
microRNA
|
mir group 1
|
NA
|
-
|
121
|
39
|
intra CNV
|
seg 39 (chr 9p)
|
NA
|
+
|
22
|
82
|
microRNA
|
mir group 2
|
NA
|
-
|
120
|
40
|
intra CNV
|
seg 12 (chr 2q)
|
NA
|
+
|
20
|
83
|
TF
|
TF group 1
|
NA
|
+
|
338
|
41
|
intra CNV
|
seg 74 (chr 19q)
|
NA
|
+
|
20
|
84
|
TF
|
TF group 2
|
NA
|
+
|
338
|
42
|
intra CNV
|
seg 83 (chr 22q)
|
NA
|
+
|
20
| | | | | | |
43
|
intra CNV
|
seg 85 (chr 23pq)
|
NA
|
+
|
20
| | | | | | |
- Index: module index. Reg: intermediate regulators. Sign: the functional direction (activation or repression) from drivers to passengers. N: number of passenger genes. Intra CNV: intra-segment CNV. Inter CNV: inter-segment CNV. TF: transcription factor expressions. The locations of segments are reported in Supplementary Table S5. Mir group 1 consists of mir-92,mir-96,mir-106a,mir 20b,mir-17,mir-19b,mir-32,mir-135,mir-25,mir-106b,mir-93,mir-106,mir-18,mir-20. Mir group 2 consists of mir-24,mir-99b,mir-27b,mir-21,mir-125a,mir-23b,mir-27a,mir-23a. TF group 1 consists of SMAD3,FOXD1,PLAU,BDNF,FOSL2,FOSL1,RBMS1. TF group 2 consists of ERG,ELK4,NFATC1,RFX3,POU5F1,ZNF350.