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Table 1 Summary information of association modules for mRNA expressions

From: Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines

index

driver type

drivers

reg

sign

N

index

driver type

drivers

reg

sign

N

1

intra CNV

seg 30 (chr 6p)

NA

+

84

44

inter CNV

seg 18 (chr 3p)

ZIC1,MITF

+

118

2

intra CNV

seg 54 (chr 12q)

NA

+

77

45

inter CNV

seg 31 (chr 6q)

TBP,MYB,HDAC2

+

77

3

intra CNV

seg 1 (chr 1p)

NA

+

74

46

inter CNV

seg 84 (chr 22q)

SREBF2,EP300

+

49

4

intra CNV

seg 57 (chr 14q)

NA

+

62

47

inter CNV

seg 30 (chr 6p)

E2F3,NFYA,SRF

+

31

5

intra CNV

seg 69 (chr 17q)

NA

+

62

48

inter CNV

seg 42 (chr 10q)

TCF7L2

+

30

6

intra CNV

seg 11 (chr 2p)

NA

+

58

49

inter CNV

seg 55 (chr 12q)

NR2C1,NFYB

+

22

7

intra CNV

seg 42 (chr 10q)

NA

+

55

50

inter CNV

seg 19 (chr 3q)

ZNF148

+

22

8

intra CNV

seg 3 (chr 1p)

NA

+

53

51

inter CNV

seg 63 (chr 16pq)

NFATC3,RBL2

+

21

9

intra CNV

seg 37 (chr 8q)

NA

+

53

52

inter CNV

seg 69 (chr 17q)

SPOP,NME2,POLG2

+

20

10

intra CNV

seg 59 (chr 14q)

NA

+

53

53

inter CNV

seg 42 (chr 10q)

NFKB2

+

19

11

intra CNV

seg 16 (chr 3p)

NA

+

49

54

inter CNV

seg 16 (chr 3p)

UBP1

+

18

12

intra CNV

seg 63 (chr 16pq)

NA

+

49

55

inter CNV

seg 83 (chr 22q)

EWSR1

+

17

13

intra CNV

seg 33 (chr 7q)

NA

+

47

56

inter CNV

seg 57 (chr 14q)

APEX1

+

16

14

intra CNV

seg 84 (chr 22q)

NA

+

47

57

inter CNV

seg 16 (chr 3p)

RPA2,EIF2C1

+

15

15

intra CNV

seg 55 (chr 12q)

NA

+

44

58

inter CNV

seg 19 (chr 3q)

CNBP

+

15

16

intra CNV

seg 51 (chr 11q)

NA

+

43

59

inter CNV

seg 51 (chr 11q)

RICS

+

14

17

intra CNV

seg 2 (chr 1p)

NA

+

42

60

inter CNV

seg 56 (chr 13q)

GTF3A

+

13

18

intra CNV

seg 73 (chr 19p)

NA

+

42

61

inter CNV

seg 4 (chr 1q)

RUNX3

+

10

19

intra CNV

seg 50 (chr 11q)

NA

+

40

62

mutation

APC

NA

+

136

20

intra CNV

seg 68 (chr 17q)

NA

+

39

63

mutation

APC

NA

-

56

21

intra CNV

seg 65 (chr 17p)

NA

+

37

64

mutation

PIK3CA

NA

+

50

22

intra CNV

seg 32 (chr 7p)

NA

+

36

65

mutation

CDKN2A

NA

-

43

23

intra CNV

seg 35 (chr 7q)

NA

+

35

66

mutation

TP53

NA

-

35

24

intra CNV

seg 31 (chr 6q)

NA

+

33

67

mutation

BRAF

NA

-

34

25

intra CNV

seg 19 (chr 3q)

NA

+

32

68

mutation

TP53

NA

+

33

26

intra CNV

seg 18 (chr 3p)

NA

+

30

69

mutation

CDKN2A

NA

+

32

27

intra CNV

seg 9 (chr 1q)

NA

+

29

70

mutation

KRAS

NA

+

25

28

intra CNV

seg 22 (chr 4p)

NA

+

29

71

mutation

PTEN

NA

+

20

29

intra CNV

seg 62 (chr 15q)

NA

+

29

72

mutation

KRAS

NA

-

16

30

intra CNV

seg 41 (chr 9q)

NA

+

28

73

mutation

BRAF

NA

+

16

31

intra CNV

seg 49 (chr 11q)

NA

+

28

74

mutation

PIK3CA

NA

-

13

32

intra CNV

seg 56 (chr 13q)

NA

+

28

75

mutation

PTEN

NA

-

13

33

intra CNV

seg 60 (chr 15q)

NA

+

28

76

methylation

PAX8

NA

-

61

34

intra CNV

seg 44 (chr 11p)

NA

+

27

77

methylation

BCR

NA

-

58

35

intra CNV

seg 61 (chr 15q)

NA

+

26

78

methylation

HOXC13

NA

-

19

36

intra CNV

seg 80 (chr 21q)

NA

+

24

79

methylation

CCND1,PPARG

NA

-

13

37

intra CNV

seg 36 (chr 8p)

NA

+

23

80

methylation

COL5A1

NA

-

10

38

intra CNV

seg 27 (chr 5q)

NA

+

22

81

microRNA

mir group 1

NA

-

121

39

intra CNV

seg 39 (chr 9p)

NA

+

22

82

microRNA

mir group 2

NA

-

120

40

intra CNV

seg 12 (chr 2q)

NA

+

20

83

TF

TF group 1

NA

+

338

41

intra CNV

seg 74 (chr 19q)

NA

+

20

84

TF

TF group 2

NA

+

338

42

intra CNV

seg 83 (chr 22q)

NA

+

20

      

43

intra CNV

seg 85 (chr 23pq)

NA

+

20

      
  1. Index: module index. Reg: intermediate regulators. Sign: the functional direction (activation or repression) from drivers to passengers. N: number of passenger genes. Intra CNV: intra-segment CNV. Inter CNV: inter-segment CNV. TF: transcription factor expressions. The locations of segments are reported in Supplementary Table S5. Mir group 1 consists of mir-92,mir-96,mir-106a,mir 20b,mir-17,mir-19b,mir-32,mir-135,mir-25,mir-106b,mir-93,mir-106,mir-18,mir-20. Mir group 2 consists of mir-24,mir-99b,mir-27b,mir-21,mir-125a,mir-23b,mir-27a,mir-23a. TF group 1 consists of SMAD3,FOXD1,PLAU,BDNF,FOSL2,FOSL1,RBMS1. TF group 2 consists of ERG,ELK4,NFATC1,RFX3,POU5F1,ZNF350.