Table 4 Primary assimilation processes in the methylotrophic network.
compound/precursor biosynthesis | number of carbon in precursor | number of EFMs | Max. molar-Yield | Max. carbon-Yield | Minimal EFM length | EMCP utilisation |
|---|---|---|---|---|---|---|
5, 10-methylenetetrahydrofolate (Me-THF) | 1 | 2018 | 1.00 | 1.00 | 20 | 93% |
acetyl-CoA | 2 | 2440 | 0.45 | 0.91 | 35 | 95% |
glycine | 2 | 2054 | 0.42 | 0.84 | 62 | 100% |
L-serine | 3 | 2162 | 0.29 | 0.88 | 62 | 100% |
D-glyceraldehyde-3-phosphate (GA3P) | 3 | 2592 | 0.27 | 0.81 | 54 | 100% |
phosphateenolpyruvate (PEP) | 3 | 3390 | 0.32 | 0.97 | 53 | 100% |
pyruvate (PYR) | 3 | 3065 | 0.33 | 1.00 | 50 | 100% |
oxaloacetate (OAA) | 4 | 5366 | 0.32 | 1.29 | 51 | 100% |
(R)-3-hydroxybutanoyl-CoA (3HBCOA) | 4 | 2789 | 0.21 | 0.83 | 37 | 92% |
D-erythrose-4-phosphate (E4P) | 4 | 6576 | 0.20 | 0.81 | 63 | 100% |
α-ketoglutarate | 5 | 3806 | 0.20 | 1.02 | 54 | 100% |
D-ribose-5-phosphate | 5 | 4663 | 0.16 | 0.81 | 61 | 100% |
D-glucose-6-phosphate | 6 | 2592 | 0.14 | 0.68 | 58 | 100% |