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Table 4 Primary assimilation processes in the methylotrophic network.

From: Genome-scale reconstruction and system level investigation of the metabolic network of Methylobacterium extorquensAM1

compound/precursor biosynthesis number of carbon in precursor number of EFMs Max. molar-Yield Max. carbon-Yield Minimal EFM length EMCP utilisation
5, 10-methylenetetrahydrofolate (Me-THF) 1 2018 1.00 1.00 20 93%
acetyl-CoA 2 2440 0.45 0.91 35 95%
glycine 2 2054 0.42 0.84 62 100%
L-serine 3 2162 0.29 0.88 62 100%
D-glyceraldehyde-3-phosphate (GA3P) 3 2592 0.27 0.81 54 100%
phosphateenolpyruvate (PEP) 3 3390 0.32 0.97 53 100%
pyruvate (PYR) 3 3065 0.33 1.00 50 100%
oxaloacetate (OAA) 4 5366 0.32 1.29 51 100%
(R)-3-hydroxybutanoyl-CoA (3HBCOA) 4 2789 0.21 0.83 37 92%
D-erythrose-4-phosphate (E4P) 4 6576 0.20 0.81 63 100%
α-ketoglutarate 5 3806 0.20 1.02 54 100%
D-ribose-5-phosphate 5 4663 0.16 0.81 61 100%
D-glucose-6-phosphate 6 2592 0.14 0.68 58 100%
  1. Number and properties of primary assimilatory EFMs detected in the methylotrophic network. The EFMs correspond to the processes allowing the conversion of methanol into 13 key carbon precursors