Cluster | Top biological functions enrichment within each cluster | Predictive abilitya | ||||
---|---|---|---|---|---|---|
 | Functional Pathways | p-valueb | # molecules | Calu-3 | Macaque | Mouse |
1 | None | Â | Â | 0.89* | 0.23 | 0.98* |
2 | cell surface receptor linked signal transduction | 1.56E-02 | 6 | 0.88* | -0.44 | 0.28 |
 | activation of eukaryotic cells | 1.56E-02 | 9 |  |  |  |
 | developmental process of antigen presenting cells | 1.56E-02 | 5 |  |  |  |
 | aggregation of blood cells | 3.09E-02 | 4 |  |  |  |
 | growth of leukocytes | 3.09E-02 | 4 |  |  |  |
 | replication of virus | 3.09E-02 | 6 |  |  |  |
3 | binding of blood cells | 5.22E-07 | 16 | 0.96* | 0.44 | 0.98* |
 | activation of granulocytes | 5.28E-07 | 11 |  |  |  |
 | stimulation of normal cells | 6.52E-07 | 13 |  |  |  |
 | inflammatory response | 6.56E-07 | 23 |  |  |  |
 | maturation of leukocytes | 6.98E-07 | 14 |  |  |  |
 | chemotaxis of cells | 9.01E-07 | 20 |  |  |  |
 | activation of monocytes | 9.65E-07 | 9 |  |  |  |
 | activation of phagocytes | 9.65E-07 | 13 |  |  |  |
 | activation of T lymphocytes | 1.09E-06 | 16 |  |  |  |
 | immune response | 2.82E-06 | 28 |  |  |  |
4 | developmental process of blood cells | 2.38E-04 | 41 | 0.99* | -0.13 | -0.99* |
 | function of lymphatic system cells | 1.95E-03 | 5 |  |  |  |
 | recruitment of normal cells | 4.40E-03 | 14 |  |  |  |
 | differentiation of lymphocytes | 4.47E-03 | 20 |  |  |  |
 | function of leukocytes (including function of granulocytes) | 5.51E-03 | 9 |  |  |  |
 | quantity of leukocytes | 5.76E-03 | 25 |  |  |  |
5 | development of intercellular junctions | 8.80E-04 | 10 | 0.83 | -0.21 | 0.92* |
6 | cell division process | 2.98E-03 | 253 | 0.96 | 0.25 | -0.97* |
 | metabolism of carbohydrate | 3.52E-02 | 80 |  |  |  |
 | transactivation | 3.52E-02 | 127 |  |  |  |
 | cell death of connective tissue cells | 3.83E-02 | 66 |  |  |  |
 | modification of DNA | 5.02E-02 | 58 |  |  |  |
7 | secretion of cytokine/recognition of cells | 2.97E-02 | 1 | 0.64 | 0.32 | 0.58 |
 | methylation of protein or DNA | 2.97E-02 | 1 |  |  |  |
8 | accumulation of calcium | 3.13E-02 | 6 | 0.97* | 0.68* | -0.86 |
 | contraction of tissue | 3.69E-02 | 16 |  |  |  |
 | neurotransmission | 3.78E-02 | 20 |  |  |  |
 | blood pressure | 3.78E-02 | 13 |  |  |  |
 | response of cells | 3.78E-02 | 24 |  |  |  |
 | synthesis of cyclic AMP | 3.78E-02 | 7 |  |  |  |
9 | None | Â | Â | 0.72 | 0.25 | 0.86 |
10 | transcription | 1.67E-08 | 150 | 0.99* | 0.72* | 0.33 |
 | protein kinase cascade (including IKKB/NFkB cascades) | 4.25E-03 | 33 |  |  |  |
 | activation of cyclin-dependent protein kinase | 5.06E-03 | 11 |  |  |  |
 | developmental process of organism | 1.62E-02 | 81 |  |  |  |
 | cell cycle progression | 2.79E-02 | 67 |  |  |  |
 | activation of protein | 4.00E-02 | 20 |  |  |  |