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Table 2 Functional enrichment of Calu-3 clusters.

From: Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems

Cluster Top biological functions enrichment within each cluster Predictive abilitya
  Functional Pathways p-valueb # molecules Calu-3 Macaque Mouse
1 None    0.89* 0.23 0.98*
2 cell surface receptor linked signal transduction 1.56E-02 6 0.88* -0.44 0.28
  activation of eukaryotic cells 1.56E-02 9    
  developmental process of antigen presenting cells 1.56E-02 5    
  aggregation of blood cells 3.09E-02 4    
  growth of leukocytes 3.09E-02 4    
  replication of virus 3.09E-02 6    
3 binding of blood cells 5.22E-07 16 0.96* 0.44 0.98*
  activation of granulocytes 5.28E-07 11    
  stimulation of normal cells 6.52E-07 13    
  inflammatory response 6.56E-07 23    
  maturation of leukocytes 6.98E-07 14    
  chemotaxis of cells 9.01E-07 20    
  activation of monocytes 9.65E-07 9    
  activation of phagocytes 9.65E-07 13    
  activation of T lymphocytes 1.09E-06 16    
  immune response 2.82E-06 28    
4 developmental process of blood cells 2.38E-04 41 0.99* -0.13 -0.99*
  function of lymphatic system cells 1.95E-03 5    
  recruitment of normal cells 4.40E-03 14    
  differentiation of lymphocytes 4.47E-03 20    
  function of leukocytes (including function of granulocytes) 5.51E-03 9    
  quantity of leukocytes 5.76E-03 25    
5 development of intercellular junctions 8.80E-04 10 0.83 -0.21 0.92*
6 cell division process 2.98E-03 253 0.96 0.25 -0.97*
  metabolism of carbohydrate 3.52E-02 80    
  transactivation 3.52E-02 127    
  cell death of connective tissue cells 3.83E-02 66    
  modification of DNA 5.02E-02 58    
7 secretion of cytokine/recognition of cells 2.97E-02 1 0.64 0.32 0.58
  methylation of protein or DNA 2.97E-02 1    
8 accumulation of calcium 3.13E-02 6 0.97* 0.68* -0.86
  contraction of tissue 3.69E-02 16    
  neurotransmission 3.78E-02 20    
  blood pressure 3.78E-02 13    
  response of cells 3.78E-02 24    
  synthesis of cyclic AMP 3.78E-02 7    
9 None    0.72 0.25 0.86
10 transcription 1.67E-08 150 0.99* 0.72* 0.33
  protein kinase cascade (including IKKB/NFkB cascades) 4.25E-03 33    
  activation of cyclin-dependent protein kinase 5.06E-03 11    
  developmental process of organism 1.62E-02 81    
  cell cycle progression 2.79E-02 67    
  activation of protein 4.00E-02 20    
  1. a asterisk indicates statistical significance versus random for predictive ability
  2. b Benjamini-Hochberg adjusted