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Table 1 Receptor densities

From: Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies

  Measured parameters Model parameters
  Value Unit Value Unit
VEGFR1     
   Luminal EC (normal) 550 rec/EC 1.21 × 10-1 pmol/cm3 tissue
   Abluminal EC (normal) 550 rec/EC 9.86 × 10-3 pmol/cm3 tissue
   Luminal EC (diseased) 3,750 rec/EC 4.38 × 10-4 pmol/cm3 tissue
   Abluminal EC (diseased) 3,750 rec/EC 6.54 × 10-2 pmol/cm3 tissue
   Myocytes 0 rec/myocyte 0 pmol/cm3 tissue
   Tumor cells 1,100 rec/tumor cell 2.81 × 10-1 pmol/cm3 tissue
VEGFR2     
   Luminal EC (normal) 350 rec/EC 7.70 × 10-2 pmol/cm3 tissue
   Abluminal EC (normal) 350 rec/EC 6.28 × 10-3 pmol/cm3 tissue
   Luminal EC (diseased) 300 rec/EC 3.51 × 10-5 pmol/cm3 tissue
   Abluminal EC (diseased) 300 rec/EC 5.23 × 10-3 pmol/cm3 tissue
   Myocytes 0 rec/myocyte 0 pmol/cm3 tissue
   Tumor cells 550 rec/tumor cell 1.41 × 10-1 pmol/cm3 tissue
NRP1     
   Luminal EC (normal) 17,500 rec/EC 3.74 pmol/cm3 tissue
   Abluminal EC (normal) 17,500 rec/EC 3.05 × 10-1 pmol/cm3 tissue
   Luminal EC (diseased) 20,000 rec/EC 2.34 × 10-3 pmol/cm3 tissue
   Abluminal EC (diseased) 20,000 rec/EC 3.49 × 10-1 pmol/cm3 tissue
   Myocytes 34,500 rec/myocyte 2.06 pmol/cm3 tissue
   Tumor cells 39,500 rec/tumor cell 1.01 × 101 pmol/cm3 tissue
NRP2     
   Luminal EC (normal) 0 rec/EC 0 pmol/cm3 tissue
   Abluminal EC (normal) 0 rec/EC 0 pmol/cm3 tissue
   Luminal EC (diseased) 0 rec/EC 0 pmol/cm3 tissue
   Abluminal EC (diseased) 0 rec/EC 0 pmol/cm3 tissue
   Myocytes 0 rec/myocyte 0 pmol/cm3 tissue
   Tumor cells 39,500 rec/tumor cell 1.02 × 101 pmol/cm3 tissue
  1. EC = endothelial cell; rec = receptors
  2. Extrapolated from receptor density on normal ECs, accounting for different cell surface areas
  3. No NRP2 quantification available; assumed to be the same as NRP1 on tumor cells
  4. Conversions of receptor densities to tissue concentrations:
  5. Abluminal EC receptors (normal): 1.79 × 10-5 (pmol/cm3 tissue)/(rec/EC);
  6. Luminal EC receptors (normal): 2.20 × 10-4 (pmol/cm3 tissue)/(rec/EC);
  7. Abluminal EC receptors (diseased): 1.74 × 10-5 (pmol/cm3 tissue)/(rec/EC);
  8. Luminal EC receptors (diseased): 1.17 × 10-7 (pmol/cm3 tissue)/(rec/EC);
  9. Myocyte receptors: 5.96 × 10-5 (pmol/cm3 tissue)/(rec/myocyte);
  10. Tumor receptors: 2.55 × 10-4 (pmol/cm3 tissue)/(rec/tumor cell);
  11. Myocyte receptor densities are expressed per myonuclear domain