SED-ML demonstration. SED-ML facilitates the exchange of simulation experiments for a number of modeling languages and supports a number of existing simulators. In this sample setup, the SBML model file BIOMD0000000021 (available from BioModels Database) was loaded into SBSIVisual, a simulation was created and then exported into the SED-ML Script editor (where the simulation can be reproduced). There the simulation was edited to carry out a simulation on a changed model. Finally, the resulting SED-ML experiment was saved as an archive and uploaded to the SED-ML Web Tools, where it was run to reproduce the simulation experiment.