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Figure 12 | BMC Systems Biology

Figure 12

From: Stochastic adaptation and fold-change detection: from single-cell to population behavior

Figure 12

Variations of key parameters in the two-state protein model, with kinases and phosphatases as discrete mediators. Columns correspond to simulations using (A-D) parameter values of Figure 11; (E-H) k a 2= k a 3= 0.01. Rows correspond to single-cell time courses of (A, E) P and (C, G) P m ; and the mean of a population of 50 cells of (B, F) P and (D, H) P m . Trajectories portray SSA simulations (blue), and input kinase signal (red).

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