Figure 6
From: A general framework for modeling growth and division of mammalian cells
Numbers of SCF bound to Fbw7, Skp2, and Btrc subunits over two cell divisions. All molecules are present at the same time. First, SCF preferentially binds Fbw7 and ubiquitinates Fbw7 substrates, at which point Fbw7 autoubiquitinates. Then SCF preferentially binds Skp2 and ubiquitinates Skp2 substrates (in particular, replication complexes RC) at which point Skp2 autoubiquitinates. Finally, SCF binds Btrc, concluding the sequence.