Figure 9
From: A general framework for modeling growth and division of mammalian cells
Numbers of Cdc14 (representing the MEN pathway) over two cell divisions. Cdc14 is a phosphatase that functions to activate p27, Wee1, and Cdh1 and deactivate the Cdc25 phosphatases, thus resetting the cell cycle after cell division. Cdc14 is constitutively expressed and rapidly translocated to the nucleus. Most of cell cycle, Cdc14 is inhibited by Securin. Cdc14 is activated when phosphorylated by nuclear Plk1after Securin is degraded.