Figure 6

Local parametric sensitivity analysis of the programmed cell death model. (a-c) The bar graphs represent the ten largest sensitivity metrics of caspase-3 based on infinite norm, Fisher Information Matrix (FIM), time integrated sensitivity coefficients, and sensitivity magnitudes at the switching time (t = 6060s). The complete parameter ranking is given in Additional file 1: Supplementary Figure S3. The parameter numbers refer to the reactions shown in Figure 5, where the subscripts f and r denote forward and backward rate constants for reversible reactions and k denotes the rate constants for irreversible reactions.