ROC curves of the leave-one-out cross-validation experiments. (A) Results for random controls. (B) Results for linkage intervals. (C) Results for genome-wide scan. BF: the domainRBF approach (using Bayes factors as scores for candidate domains). R2: the ordinary non-Bayesian linear regression approach (using R-square as scores for candidate domains). SG: shortest path with Gaussian kernel. DK: diffusion kernel. Numbers in the parentheses are AUC scores of the corresponding ROC curves. The small domain-domain interaction network composed of the PDB part of the DOMINE database is used to obtain the results.