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Table 4 Protein concentrations of CYP3A4 and UGT1A3 in primary human hepatocytes

From: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Individual CYP3A4 [pmol ml-1] UGT1A3 [-]
1 1027 ± 107 (n = 2) 1.00
2 611 ± 120 (n = 4) 0.29
3 755 ± 19 (n = 2) 0.10
  1. Protein concentrations were calculated from total CYP3A4 and UGT1A3 content per sample divided by total intracellular volume of hepatocytes, respectively. Protein concentrations of CYP3A4 are listed in mean and standard deviation in the units pmol per ml intracellular volume. Relative protein concentrations of UGT1A3 are normalized to individual 1.