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Table 2 Description and range of the parameters varied in the simulations with the mouse ventricular myocyte model

From: Hierarchical Cluster-based Partial Least Squares Regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models

Parameter name Unit Description Minimum value Baseline value Maximum value
Ko uM Extracellular potassium concentration 2700 5400 8100
Nao uM Extracellular sodium concentration 67000 134000 201000
Cao uM Extracellular calcium concentration 700 1400 2100
stim_period ms Stimulus period 166.67 333.33 500
vmup_init uM/ms SERCA, calcium uptake from cytosol to sarcoplasmic reticulum 0.2530 0.5059 0.7589
P_CaL 1/ms L-type calcium current 1.25 2.5 3.75
V_max_NCX pA/pF NCX, scaling coefficient for the sodium-calcium exchanger current 1.9695 3.9390 5.9085
g_Na mS/uF Fast sodium current 8 16 24
g_K1 mS/uF Time-independent potassium current 0.1750 0.35 0.5250
g_Kr mS/uF Rapid delayed rectifier potassium current 0.0083 0.0165 0.0248