Table 2 Description and range of the parameters varied in the simulations with the mouse ventricular myocyte model
Parameter name | Unit | Description | Minimum value | Baseline value | Maximum value |
|---|---|---|---|---|---|
Ko | uM | Extracellular potassium concentration | 2700 | 5400 | 8100 |
Nao | uM | Extracellular sodium concentration | 67000 | 134000 | 201000 |
Cao | uM | Extracellular calcium concentration | 700 | 1400 | 2100 |
stim_period | ms | Stimulus period | 166.67 | 333.33 | 500 |
vmup_init | uM/ms | SERCA, calcium uptake from cytosol to sarcoplasmic reticulum | 0.2530 | 0.5059 | 0.7589 |
P_CaL | 1/ms | L-type calcium current | 1.25 | 2.5 | 3.75 |
V_max_NCX | pA/pF | NCX, scaling coefficient for the sodium-calcium exchanger current | 1.9695 | 3.9390 | 5.9085 |
g_Na | mS/uF | Fast sodium current | 8 | 16 | 24 |
g_K1 | mS/uF | Time-independent potassium current | 0.1750 | 0.35 | 0.5250 |
g_Kr | mS/uF | Rapid delayed rectifier potassium current | 0.0083 | 0.0165 | 0.0248 |