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Table 7 Observed extracellular rates for several metabolic phases within three fed-batch cultures

From: Cell functional enviromics: Unravelling the function of environmental factors

  Fed-batch 1 Fed-batch 2 Fed-batch 3
Robs Ph I Ph II Ph III Ph IV Ph I Ph II Ph III Ph IV Ph V Ph I Ph II Ph III Ph IV Ph V
  (21-45 h) (45-70 h) (70-95 h) (95-118 h) (25-50 h) (50-70 h) (70-90 h) (90-110 h) (110-135 h) (50-75 h) (75-100 h) (100-125 h) (125-150 h) (150-175 h)
μ 0.019 0.022 0.022 0.012 0.020 0.020 0.018 0.014 0.009 0.020 0.017 0.014 0.009 0.008
rGlc -190.33 -76.60 -71.99 -50.89 -187.25 -88.71 -74.53 -78.89 -51.89 -99.03 -71.38 -99.38 -63.53 -75.45
rGln -8.74 -3.56 -5.24 -4.31 -10.23 -7.39 -2.02 -1.85 -1.20 -12.46 -3.73 -2.85 -1.47 -1.62
rLac 324.81 68.80 19.97 8.95 206.02 116.56 76.71 59.78 46.56 94.97 32.10 59.04 24.52 17.45
rAmm 9.85 12.94 10.50 9.68 16.32 12.75 9.88 8.17 6.34 9.83 9.40 12.91 14.04 12.47
rIgG 0.000215 0.000326 0.000291 0.000224 0.000167 0.000257 0.000301 0.000308 0.000264 0.000214 0.000280 0.000317 0.000368 0.000465
rGlu 3.90 -8.26 -15.43 -14.25 5.86 -9.97 -14.42 -18.72 -13.34 -3.49 -9.18 -12.19 -10.96 -13.61
rAla 0.13 -2.63 -2.83 -1.91 0.45 -2.34 -3.00 -2.27 -1.54 -1.65 -4.23 -4.16 -1.93 -0.56
rAsp -15.89 -14.38 -8.20 -0.54 -12.71 -9.51 -2.22 -0.50 0.01 -5.96 -4.52 -4.34 -2.93 -2.33
rSer -19.18 -16.59 -14.63 -3.06 -13.63 -10.89 -13.84 -14.43 -7.80 -15.58 -11.79 -10.03 -5.69 -4.47
rAsn 2.91 -3.98 -3.24 -2.31 -3.30 -3.05 -2.55 -1.86 -1.45 0.30 -2.37 -3.96 -2.96 -2.70
rGly 13.83 7.17 1.26 -0.01 9.50 7.34 6.18 5.84 5.16 8.53 6.30 3.66 1.93 0.47
rHis -3.17 -2.80 -1.67 0.87 -1.08 -1.10 -0.65 -0.67 -0.47 -2.53 -0.78 -0.73 -0.52 -0.56
rThr -3.30 -3.65 -3.47 -1.79 -2.99 -2.95 -2.53 -1.74 -1.30 -2.58 -2.10 -2.47 -1.37 -1.33
rArg -3.15 -2.88 -3.38 -1.93 -2.88 -2.88 -2.55 -2.52 -1.41 -2.69 -2.35 -2.27 -1.47 -1.26
rPro -5.84 -5.27 -1.81 -1.00 -5.82 -2.93 -0.83 0.90 1.60 9.34 2.41 -1.07 -0.39 -0.09
rTyr -1.75 -1.35 -1.56 -1.13 -1.97 -1.41 -0.58 -0.39 -0.21 -1.17 -1.13 -1.02 -0.75 -1.08
rCys -2.97 -2.58 -1.59 -0.88 -3.03 -1.45 -2.98 -3.34 -1.84 -3.36 -2.63 -2.54 -1.69 -1.41
rVal -3.51 -3.84 -3.68 -2.04 -2.96 -2.82 -2.53 -2.20 -1.40 -2.56 -2.03 -2.50 -1.95 -1.77
rMet -3.06 -4.76 -2.46 -0.72 -2.35 -1.89 -1.35 -0.82 -0.50 -1.68 -1.06 -1.46 -1.21 -1.32
rIle -2.52 -3.16 -2.59 -1.54 -2.89 -2.40 -1.99 -1.41 -1.12 -1.93 -1.59 -1.68 -1.68 -1.47
rLeu -4.66 -5.52 -5.11 -2.67 -5.01 -4.51 -3.47 -2.90 -1.85 -3.83 -3.07 -4.68 -3.29 -2.74
rLys -5.62 -4.46 -4.27 -2.32 -5.25 -4.08 -3.35 -2.59 -2.07 -3.31 -3.62 -4.77 -2.96 -1.65
rPhe -2.69 -2.27 -1.83 -0.75 -1.70 -1.60 -1.94 -3.25 -1.03 -0.98 -0.93 -0.98 -0.79 -0.80
  1. Units are in nmol.(106cells.h)-1. A minus sign indicates consumption. μ refers to the specific growth rate (h-1), calculated using the concentrations of viable cells