Anti-angiogenesis synergistic effects of five agent pairs. a-e. The red line denotes the inhibition rate of Human Umbilical Vein Endothelial Cells (HUVEC) proliferation in a dose-dependent manner. The blue line denotes the additive effects calculated by the Bliss independence model. The gray column denotes the optimal dose and ratio of each pair. f. The value of the maximum increased inhibition rate (MIIR) for the synergistic effects produced by five agent pairs corresponds well with the NIMS ranks against the angiogenesis network. The proportion of two agents is determined by following the same ratio of the two agent’s IC50 values.