TF-regulatory gene expression networks in 16-20w WKY (A) and GK (B). The node color and form are drawn by the same way as Figures 1 and 5, respectively. Nuclear receptors play important role maintaining the non-diabetic stage in WKY strain. In GK rats, some compensational pathways still exist. However, genes involved in insulin resistance, hypertension and apoptosis are able to cause diabetes progression.